Version 5.4
Mus musculus Gene: Lrpap1
Summary
InnateDB Gene IDBG-156700.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lrpap1
Gene Name low density lipoprotein receptor-related protein associated protein 1
Synonyms AA617339; AI790446; AU042172; C77774; HBP44; RAP
Species Mus musculus
Ensembl Gene ENSMUSG00000029103
Encoded Proteins
IDBP-156702
low density lipoprotein receptor-related protein associated protein 1
IDBP-537230
low density lipoprotein receptor-related protein associated protein 1
IDBP-532728
low density lipoprotein receptor-related protein associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163956:
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:35091490-35105766
Strand Reverse strand
Band B2
Transcripts
ENSMUST00000030986 ENSMUSP00000030986
ENSMUST00000153664 ENSMUSP00000120233
ENSMUST00000135207
ENSMUST00000147028
ENSMUST00000152028
ENSMUST00000132754 ENSMUSP00000116145
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0035473 lipase binding
GO:0048019 receptor antagonist activity
GO:0050750 low-density lipoprotein particle receptor binding
GO:0070326 very-low-density lipoprotein particle receptor binding
Biological Process
GO:0010916 negative regulation of very-low-density lipoprotein particle clearance
GO:0032091 negative regulation of protein binding
GO:1900116 extracellular negative regulation of signal transduction
GO:1900222 negative regulation of beta-amyloid clearance
Cellular Component
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031982 vesicle
GO:0048237 rough endoplasmic reticulum lumen
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163956
View Gene Order
ENSBTAG00000000073
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
reelinpathway
Reelin signaling pathway
hedgehog_2pathway
Signaling events mediated by the Hedgehog family
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.277661 Mm.397794 Mm.452112
RefSeq NM_013587
OMIM
CCDS CCDS19225
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca