Version 5.4
Mus musculus Gene: H2afx
Summary
InnateDB Gene IDBG-156783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2afx
Gene Name H2A histone family, member X
Synonyms AW228881; gammaH2ax; H2A.X; H2ax; Hist5-2ax
Species Mus musculus
Ensembl Gene ENSMUSG00000049932
Encoded Proteins
IDBP-156785
H2A histone family, member X
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188486:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:44334694-44336077
Strand Forward strand
Band A5.2
Transcripts
ENSMUST00000052686 ENSMUSP00000051432
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 217 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 217 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042393 histone binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000077 DNA damage checkpoint
GO:0000724 double-strand break repair via homologous recombination
GO:0006281 DNA repair
GO:0006334 nucleosome assembly
GO:0006974 cellular response to DNA damage stimulus
GO:0007126 meiotic nuclear division
GO:0007283 spermatogenesis
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000790 nuclear chromatin
GO:0000794 condensed nuclear chromosome
GO:0001673 male germ cell nucleus
GO:0001741 XY body
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005694 chromosome
GO:0035861 site of double-strand break
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000188486
View Gene Order
ENSBTAG00000038047
Not yet available
Pathways
NETPATH
REACTOME
REACT_27235
Meiotic Recombination pathway
REACT_75800
Meiotic Synapsis pathway
REACT_251314
ATM mediated phosphorylation of repair proteins pathway
REACT_245058
RNA Polymerase I Transcription pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_200794
Mus musculus biological processes pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_200667
NoRC negatively regulates rRNA expression pathway
REACT_218274
Chromatin organization pathway
REACT_189085
Disease pathway
REACT_233453
Chromosome Maintenance pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_230172
Recruitment of repair and signaling proteins to double-strand breaks pathway
REACT_261629
MRN complex relocalizes to nuclear foci pathway
REACT_188957
Cellular responses to stress pathway
REACT_198563
Amyloids pathway
REACT_256157
RNA Polymerase I Promoter Opening pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_238355
Double-Strand Break Repair pathway
REACT_222475
PRC2 methylates histones and DNA pathway
REACT_198626
Meiotic synapsis pathway
REACT_252672
Telomere Maintenance pathway
REACT_188804
Cell Cycle pathway
REACT_256555
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks pathway
REACT_214440
NoRC negatively regulates rRNA expression pathway
REACT_241408
M Phase pathway
REACT_196580
Condensation of Prophase Chromosomes pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_233397
DNA Repair pathway
REACT_216539
formation of the beta-catenin:TCF transactivating complex pathway
REACT_188820
Cellular Senescence pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_270446
Transcriptional regulation by small RNAs pathway
REACT_226125
Packaging Of Telomere Ends pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_224328
SIRT1 negatively regulates rRNA Expression pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_233572
Gene Expression pathway
REACT_268475
DNA methylation pathway
REACT_207809
Negative epigenetic regulation of rRNA expression pathway
REACT_198595
Nucleosome assembly pathway
REACT_198597
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_206535
Regulatory RNA pathways pathway
REACT_244207
RMTs methylate histone arginines pathway
REACT_250557
Mitotic Prophase pathway
REACT_188257
Signal Transduction pathway
REACT_198624
Meiosis pathway
REACT_198629
Meiotic recombination pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_259097
RNA Polymerase I Chain Elongation pathway
REACT_245922
Homologous Recombination Repair pathway
REACT_237642
ATM mediated response to DNA double-strand break pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_251264
Homologous recombination repair of replication-independent double-strand breaks pathway
KEGG
mmu05322
Systemic lupus erythematosus pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_7963
Packaging Of Telomere Ends pathway
REACT_75925
Amyloids pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_2232
RNA Polymerase I Promoter Opening pathway
REACT_486
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks pathway
REACT_1884
MRN complex relocalizes to nuclear foci pathway
REACT_97
Recruitment of repair and signaling proteins to double-strand breaks pathway
REACT_1924
ATM mediated phosphorylation of repair proteins pathway
REACT_204
ATM mediated response to DNA double-strand break pathway
REACT_27271
Meiotic recombination pathway
REACT_120956
Cellular responses to stress pathway
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_1874
Homologous Recombination Repair pathway
REACT_172744
Condensation of Prophase Chromosomes pathway
REACT_11045
Signaling by Wnt pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_267668
Transcriptional regulation by small RNAs pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_7970
Telomere Maintenance pathway
REACT_111102
Signal Transduction pathway
REACT_200827
SIRT1 negatively regulates rRNA Expression pathway
REACT_2054
Double-Strand Break Repair pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_267652
DNA methylation pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_172623
Chromatin organization pathway
REACT_765
Mitotic Prophase pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_1587
Homologous recombination repair of replication-independent double-strand breaks pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_200753
formation of the beta-catenin:TCF transactivating complex pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_111183
Meiosis pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_216
DNA Repair pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
hsa05322
Systemic lupus erythematosus pathway
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
atm_pathway
ATM pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.245931
RefSeq NM_010436
OMIM
CCDS CCDS23105
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca