Version 5.4
Mus musculus Gene: Gpt
Summary
InnateDB Gene IDBG-156798.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpt
Gene Name glutamic pyruvic transaminase, soluble
Synonyms 1300007J06Rik; 2310022B03Rik; ALT; Gpt-1; Gpt1
Species Mus musculus
Ensembl Gene ENSMUSG00000022546
Encoded Proteins
IDBP-156800
glutamic pyruvic transaminase, soluble
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167701:
This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:76696764-76699674
Strand Forward strand
Band D3
Transcripts
ENSMUST00000023203 ENSMUSP00000023203
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009058 biosynthetic process
GO:0042853 L-alanine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167701
View Gene Order
ENSBTAG00000007835
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_239550
Amino acid synthesis and interconversion (transamination) pathway
KEGG
mmu00250
Alanine, aspartate and glutamate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_238
Amino acid synthesis and interconversion (transamination) pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_226362
Metabolism of amino acids and derivatives pathway
REACT_219139
Metabolism pathway
REACT_217400
Amino acid synthesis and interconversion (transamination) pathway
KEGG
hsa00250
Alanine, aspartate and glutamate metabolism pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Alanine Aspartate Asparagine metabolism pathway
PID NCI
Cross-References
SwissProt Q8QZR5
TrEMBL Q566C3
UniProt Splice Variant
Entrez Gene 76282
UniGene
RefSeq NM_182805
OMIM
CCDS CCDS27586
HPRD
IMGT
MGI ID MGI:95802
MGI Symbol Gpt
EMBL BC022625 BC026846 BK005127 CH466545
GenPept AAH22625 AAH26846 DAA05289 EDL29605
RNA Seq Atlas 76282

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca