Mus musculus Gene: Apex1
Summary
InnateDB Gene IDBG-156891.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apex1
Gene Name apurinic/apyrimidinic endonuclease 1
Synonyms APE; Apex; HAP1; Ref-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000035960
Encoded Proteins
apurinic/apyrimidinic endonuclease 1
apurinic/apyrimidinic endonuclease 1
apurinic/apyrimidinic endonuclease 1
apurinic/apyrimidinic endonuclease 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100823:
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5\' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:50924968-50927139
Strand Forward strand
Band C1
Transcripts
ENSMUST00000049411 ENSMUSP00000042602
ENSMUST00000136753 ENSMUSP00000123148
ENSMUST00000154288 ENSMUSP00000122343
ENSMUST00000128395 ENSMUSP00000116319
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004521 endoribonuclease activity
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016491 oxidoreductase activity
GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base
GO:0031490 chromatin DNA binding
GO:0032403 protein complex binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007568 aging
GO:0010243 response to organonitrogen compound
GO:0014912 negative regulation of smooth muscle cell migration
GO:0042493 response to drug
GO:0043488 regulation of mRNA stability
GO:0045454 cell redox homeostasis
GO:0045739 positive regulation of DNA repair
GO:0055114 oxidation-reduction process
GO:0070301 cellular response to hydrogen peroxide
GO:0071320 cellular response to cAMP
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0080111 DNA demethylation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0016607 nuclear speck
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Processive synthesis on the lagging strand pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
Transcription-coupled NER (TC-NER) pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Displacement of DNA glycosylase by APE1 pathway
Chromosome Maintenance pathway
Synthesis of DNA pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
DNA strand elongation pathway
DNA Replication pathway
Base Excision Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Global Genomic NER (GG-NER) pathway
Double-Strand Break Repair pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Telomere Maintenance pathway
Cell Cycle pathway
Nucleotide Excision Repair pathway
DNA Repair pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Resolution of D-loop structures through Holliday junction intermediates pathway
Removal of DNA patch containing abasic residue pathway
Resolution of D-loop structures pathway
Mismatch Repair pathway
Extension of Telomeres pathway
Processive synthesis on the C-strand of the telomere pathway
Lagging Strand Synthesis pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Resolution of Abasic Sites (AP sites) pathway
Homologous Recombination Repair pathway
S Phase pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
KEGG
Base excision repair pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TSH pathway
REACTOME
DNA Replication pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Transcription-coupled NER (TC-NER) pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
Synthesis of DNA pathway
Homologous Recombination Repair pathway
Resolution of Abasic Sites (AP sites) pathway
S Phase pathway
Chromosome Maintenance pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
Double-Strand Break Repair pathway
Resolution of D-loop structures through Holliday junction intermediates pathway
Removal of DNA patch containing abasic residue pathway
Cell Cycle pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Resolution of D-loop structures pathway
Base Excision Repair pathway
Processive synthesis on the lagging strand pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Displacement of DNA glycosylase by APE1 pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Mismatch Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Processive synthesis on the C-strand of the telomere pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Nucleotide Excision Repair pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
DNA Repair pathway
Homologous Recombination Repair pathway
S Phase pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Extension of Telomeres pathway
Transcription-coupled NER (TC-NER) pathway
DNA Replication pathway
Telomere Maintenance pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Resolution of Abasic Sites (AP sites) pathway
Nucleotide Excision Repair pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Global Genomic NER (GG-NER) pathway
Displacement of DNA glycosylase by APE1 pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Processive synthesis on the lagging strand pathway
Processive synthesis on the C-strand of the telomere pathway
Synthesis of DNA pathway
Cell Cycle pathway
DNA Repair pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Lagging Strand Synthesis pathway
Mismatch Repair pathway
Resolution of D-loop structures pathway
Removal of DNA patch containing abasic residue pathway
Base Excision Repair pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
Chromosome Maintenance pathway
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
Resolution of D-loop structures through Holliday junction intermediates pathway
Double-Strand Break Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
DNA strand elongation pathway
KEGG
Base excision repair pathway
INOH
PID BIOCARTA
Granzyme a mediated apoptosis pathway [Biocarta view]
PID NCI
HIF-2-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.203 Mm.488643
RefSeq NM_009687 XM_006518456
OMIM
CCDS CCDS27027
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas