Version 5.4
Mus musculus Gene: Apex1
Summary
InnateDB Gene IDBG-156891.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apex1
Gene Name apurinic/apyrimidinic endonuclease 1
Synonyms APE; Apex; HAP1; Ref-1
Species Mus musculus
Ensembl Gene ENSMUSG00000035960
Encoded Proteins
IDBP-156893
apurinic/apyrimidinic endonuclease 1
IDBP-541873
apurinic/apyrimidinic endonuclease 1
IDBP-538457
apurinic/apyrimidinic endonuclease 1
IDBP-540358
apurinic/apyrimidinic endonuclease 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100823:
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5\' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:50924968-50927139
Strand Forward strand
Band C1
Transcripts
ENSMUST00000049411 ENSMUSP00000042602
ENSMUST00000136753 ENSMUSP00000123148
ENSMUST00000154288 ENSMUSP00000122343
ENSMUST00000128395 ENSMUSP00000116319
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004521 endoribonuclease activity
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016491 oxidoreductase activity
GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base
GO:0031490 chromatin DNA binding
GO:0032403 protein complex binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007568 aging
GO:0010243 response to organonitrogen compound
GO:0014912 negative regulation of smooth muscle cell migration
GO:0042493 response to drug
GO:0043488 regulation of mRNA stability
GO:0045454 cell redox homeostasis
GO:0045739 positive regulation of DNA repair
GO:0055114 oxidation-reduction process
GO:0070301 cellular response to hydrogen peroxide
GO:0071320 cellular response to cAMP
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0080111 DNA demethylation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005813 centrosome
GO:0016607 nuclear speck
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100823
View Gene Order
ENSBTAG00000002745
Not yet available
Pathways
NETPATH
REACTOME
REACT_262992
Processive synthesis on the lagging strand pathway
REACT_219627
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_213655
Transcription-coupled NER (TC-NER) pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_202316
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_220827
Displacement of DNA glycosylase by APE1 pathway
REACT_233453
Chromosome Maintenance pathway
REACT_258062
Synthesis of DNA pathway
REACT_231541
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_241296
DNA strand elongation pathway
REACT_232628
DNA Replication pathway
REACT_245705
Base Excision Repair pathway
REACT_227394
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_238177
Global Genomic NER (GG-NER) pathway
REACT_238355
Double-Strand Break Repair pathway
REACT_237585
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_252672
Telomere Maintenance pathway
REACT_188804
Cell Cycle pathway
REACT_235422
Nucleotide Excision Repair pathway
REACT_233397
DNA Repair pathway
REACT_220175
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_246095
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_245353
Resolution of D-loop structures through Holliday junction intermediates pathway
REACT_219337
Removal of DNA patch containing abasic residue pathway
REACT_262901
Resolution of D-loop structures pathway
REACT_236124
Mismatch Repair pathway
REACT_252545
Extension of Telomeres pathway
REACT_223154
Processive synthesis on the C-strand of the telomere pathway
REACT_245263
Lagging Strand Synthesis pathway
REACT_240368
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_250836
Resolution of Abasic Sites (AP sites) pathway
REACT_245922
Homologous Recombination Repair pathway
REACT_253623
S Phase pathway
REACT_251264
Homologous recombination repair of replication-independent double-strand breaks pathway
KEGG
mmu03410
Base excision repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
REACTOME
REACT_8027
Processive synthesis on the C-strand of the telomere pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_1385
Processive synthesis on the lagging strand pathway
REACT_74
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_1998
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_977
Resolution of D-loop structures through Holliday junction intermediates pathway
REACT_1064
Displacement of DNA glycosylase by APE1 pathway
REACT_1357
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_933
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_2192
Removal of DNA patch containing abasic residue pathway
REACT_1128
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_1874
Homologous Recombination Repair pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_7970
Telomere Maintenance pathway
REACT_2054
Double-Strand Break Repair pathway
REACT_115566
Cell Cycle pathway
REACT_228145
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_2229
Resolution of D-loop structures pathway
REACT_1104
Base Excision Repair pathway
REACT_1587
Homologous recombination repair of replication-independent double-strand breaks pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_228013
Mismatch Repair pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_216
DNA Repair pathway
REACT_218662
Homologous Recombination Repair pathway
REACT_225014
S Phase pathway
REACT_217593
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_209654
Extension of Telomeres pathway
REACT_227775
Transcription-coupled NER (TC-NER) pathway
REACT_213604
DNA Replication pathway
REACT_221747
Telomere Maintenance pathway
REACT_237773
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_204980
Resolution of Abasic Sites (AP sites) pathway
REACT_212448
Nucleotide Excision Repair pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_214477
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_222458
Global Genomic NER (GG-NER) pathway
REACT_203635
Displacement of DNA glycosylase by APE1 pathway
REACT_202907
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_221571
Processive synthesis on the lagging strand pathway
REACT_205725
Processive synthesis on the C-strand of the telomere pathway
REACT_224922
Synthesis of DNA pathway
REACT_214934
Cell Cycle pathway
REACT_204262
DNA Repair pathway
REACT_233731
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_214081
Lagging Strand Synthesis pathway
REACT_235284
Mismatch Repair pathway
REACT_213427
Resolution of D-loop structures pathway
REACT_227100
Removal of DNA patch containing abasic residue pathway
REACT_202612
Base Excision Repair pathway
REACT_206866
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_227796
Chromosome Maintenance pathway
REACT_218762
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_211321
Resolution of D-loop structures through Holliday junction intermediates pathway
REACT_221430
Double-Strand Break Repair pathway
REACT_218453
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_211470
Homologous recombination repair of replication-independent double-strand breaks pathway
REACT_203054
DNA strand elongation pathway
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
hif2pathway
HIF-2-alpha transcription factor network
Cross-References
SwissProt
TrEMBL D3Z6R9
UniProt Splice Variant
Entrez Gene 11792
UniGene Mm.203 Mm.488643
RefSeq NM_009687 XM_006518456
OMIM
CCDS CCDS27027
HPRD
IMGT
MGI ID MGI:88042
MGI Symbol Apex1
EMBL AC027184
GenPept
RNA Seq Atlas 11792

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca