Mus musculus Gene: Hk1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-157046.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Hk1 | ||||||||||||||||||||||
Gene Name | hexokinase 1 | ||||||||||||||||||||||
Synonyms | BB404130; dea; Hk-1; Hk1-s; mHk1-s | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000037012 | ||||||||||||||||||||||
Encoded Proteins |
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
hexokinase 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156515:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 10:62268855-62379908 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | B4 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Disease pathway
SLC-mediated transmembrane transport pathway
Metabolism pathway
Glucose transport pathway
Transmembrane transport of small molecules pathway
Hexose transport pathway
Glycogen storage diseases pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
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KEGG |
Amino sugar and nucleotide sugar metabolism pathway
Type II diabetes mellitus pathway
Fructose and mannose metabolism pathway
Insulin signaling pathway pathway
Glycolysis / Gluconeogenesis pathway
Starch and sucrose metabolism pathway
Galactose metabolism pathway
Carbohydrate digestion and absorption pathway
Butirosin and neomycin biosynthesis pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Glucose transport pathway
Hexose transport pathway
Transmembrane transport of small molecules pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Disease pathway
Glycogen storage diseases pathway
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KEGG |
Galactose metabolism pathway
Glycolysis / Gluconeogenesis pathway
Amino sugar and nucleotide sugar metabolism pathway
Insulin signaling pathway pathway
Starch and sucrose metabolism pathway
Fructose and mannose metabolism pathway
Type II diabetes mellitus pathway
Carbohydrate digestion and absorption pathway
Butirosin and neomycin biosynthesis pathway
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INOH |
Glycolysis Gluconeogenesis pathway
Aminosugars metabolism pathway
Fructose Mannose metabolism pathway
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PID NCI |
HIF-1-alpha transcription factor network
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_001146100 NM_010438 XM_006513242 XM_006513244 XM_006513245 XM_006513246 XM_006513247 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS48577 CCDS48578 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||