Mus musculus Gene: F8 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-157124.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | F8 | ||||||||||||||
Gene Name | coagulation factor VIII | ||||||||||||||
Synonyms | Cf-8; Cf8; FVIII | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Gene | ENSMUSG00000031196 | ||||||||||||||
Encoded Proteins |
coagulation factor VIII
coagulation factor VIII
coagulation factor VIII
coagulation factor VIII
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185010:
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008] This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome X:75172715-75382615 | ||||||||||||||
Strand | Reverse strand | ||||||||||||||
Band | A7.3 | ||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Platelet degranulation pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Intrinsic Pathway pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Response to elevated platelet cytosolic Ca2+ pathway
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KEGG |
Complement and coagulation cascades pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Intrinsic Pathway pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet activation, signaling and aggregation pathway
Hemostasis pathway
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KEGG |
Complement and coagulation cascades pathway
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INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | B2RRC9 B7ZNH8 D3YW61 Q684Q7 Q8BQ43 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 14069 | ||||||||||||||
UniGene | Mm.1805 | ||||||||||||||
RefSeq | NM_001161373 NM_001161374 NM_007977 XM_006527789 XM_006527791 XM_006527792 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS53114 CCDS30238 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
MGI ID | MGI:88383 | ||||||||||||||
MGI Symbol | F8 | ||||||||||||||
EMBL | AJ627040 AK051579 AL731844 AL808110 BC138347 BC145245 | ||||||||||||||
GenPept | AAI38348 AAI45246 BAC34681 CAF25309 | ||||||||||||||
RNA Seq Atlas | 14069 | ||||||||||||||