InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Taf11

Summary

InnateDB Gene

IDBG-157327.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taf11

Gene Name

TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Synonyms

1110038O14Rik; 28kDa; AI115401; AL024207; AW552398; PRO214; TAF2I; TAFII28

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024218

Encoded Proteins

IDBP-157329

TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor

IDBP-250909

TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000064995:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:27901122-27909242

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000025057	ENSMUSP00000025057
ENSMUST00000114848	ENSMUSP00000110498
ENSMUST00000155667

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0042809	vitamin D receptor binding
GO:0043565	sequence-specific DNA binding
GO:0046966	thyroid hormone receptor binding
GO:0046982	protein heterodimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0043923	positive regulation by host of viral transcription