Mus musculus Gene: Dcc
Summary
InnateDB Gene IDBG-157336.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dcc
Gene Name deleted in colorectal carcinoma
Synonyms C030036D22Rik; Igdcc1;
Species Mus musculus
Ensembl Gene ENSMUSG00000060534
Encoded Proteins
deleted in colorectal carcinoma
deleted in colorectal carcinoma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187323:
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:71258738-72351069
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000073379 ENSMUSP00000073094
ENSMUST00000114943 ENSMUSP00000110593
ENSMUST00000126030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005042 netrin receptor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0001764 neuron migration
GO:0001975 response to amphetamine
GO:0006915 apoptotic process
GO:0007411 axon guidance
GO:0010976 positive regulation of neuron projection development
GO:0021965 spinal cord ventral commissure morphogenesis
GO:0033563 dorsal/ventral axon guidance
GO:0033564 anterior/posterior axon guidance
GO:0038007 netrin-activated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0032584 growth cone membrane
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Apoptosis pathway
Netrin-1 signaling pathway
Role of DCC in regulating apoptosis pathway
Role of second messengers in netrin-1 signaling pathway
DSCAM interactions pathway
DCC mediated attractive signaling pathway
Regulation of Apoptosis pathway
Axon guidance pathway
Developmental Biology pathway
Netrin mediated repulsion signals pathway
Cell-Cell communication pathway
KEGG
Axon guidance pathway
Pathways in cancer pathway
Colorectal cancer pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Cell-Cell communication pathway
Axon guidance pathway
Apoptosis pathway
Netrin-1 signaling pathway
Role of second messengers in netrin-1 signaling pathway
Role of DCC in regulating apoptosis pathway
DCC mediated attractive signaling pathway
DSCAM interactions pathway
Regulation of Apoptosis pathway
Netrin mediated repulsion signals pathway
KEGG
Axon guidance pathway
Pathways in cancer pathway
Colorectal cancer pathway
INOH
PID BIOCARTA
PID NCI
Netrin-mediated signaling events
Cross-References
SwissProt P70211
TrEMBL
UniProt Splice Variant
Entrez Gene 13176
UniGene Mm.167882
RefSeq NM_007831 XM_006525588
OMIM
CCDS CCDS29336
HPRD
IMGT
MGI ID MGI:94869
MGI Symbol Dcc
EMBL AC105957 AC107230 AC109179 AC109499 AC121523 AC136637 AC161177 AC163492 AC167547 AC167548 AC167549 CH466528 X85788
GenPept CAA59786 EDL09563
RNA Seq Atlas 13176