InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dcc

Summary

InnateDB Gene

IDBG-157336.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dcc

Gene Name

deleted in colorectal carcinoma

Synonyms

C030036D22Rik; Igdcc1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000060534

Encoded Proteins

IDBP-157338

deleted in colorectal carcinoma

IDBP-250696

deleted in colorectal carcinoma

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187323:
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:71258738-72351069

Strand

Reverse strand

Band

Transcripts

ENSMUST00000073379	ENSMUSP00000073094
ENSMUST00000114943	ENSMUSP00000110593
ENSMUST00000126030

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005042	netrin receptor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001764	neuron migration
GO:0001975	response to amphetamine
GO:0006915	apoptotic process
GO:0007411	axon guidance
GO:0010976	positive regulation of neuron projection development
GO:0021965	spinal cord ventral commissure morphogenesis
GO:0033563	dorsal/ventral axon guidance
GO:0033564	anterior/posterior axon guidance
GO:0038007	netrin-activated signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:2001141	regulation of RNA biosynthetic process