InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lipe

Summary

InnateDB Gene

IDBG-157570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lipe

Gene Name

lipase, hormone sensitive

Synonyms

4933403G17Rik; HSL

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003123

Encoded Proteins

IDBP-157572

lipase, hormone sensitive

IDBP-157574

lipase, hormone sensitive

IDBP-271467

lipase, hormone sensitive

IDBP-532573

lipase, hormone sensitive

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079435:
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:25379527-25398710

Strand

Reverse strand

Band

Transcripts

ENSMUST00000003207	ENSMUSP00000003207
ENSMUST00000054301	ENSMUSP00000050935
ENSMUST00000105177	ENSMUSP00000100811
ENSMUST00000149349	ENSMUSP00000123485

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004806	triglyceride lipase activity
GO:0005515	protein binding
GO:0016298	lipase activity
GO:0016787	hydrolase activity
GO:0019901	protein kinase binding
GO:0033878	hormone-sensitive lipase activity
GO:0042134	rRNA primary transcript binding

Biological Process

GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0008152	metabolic process
GO:0008203	cholesterol metabolic process
GO:0016042	lipid catabolic process
GO:0019433	triglyceride catabolic process
GO:0042758	long-chain fatty acid catabolic process
GO:0046340	diacylglycerol catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0005901	caveola

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000079435

View Gene Order

ENSBTAG00000038321

Not yet available

Pathways

NETPATH

REACTOME

REACT_245618

Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway

REACT_188937

Metabolism pathway

REACT_232291

Metabolism of lipids and lipoproteins pathway

REACT_238381

Lipid digestion, mobilization, and transport pathway

KEGG

mmu04910

Insulin signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_494

Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

REACT_602

Lipid digestion, mobilization, and transport pathway

KEGG

hsa04910

Insulin signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

P54310

TrEMBL

E9Q4M2 Q6LCY9 Q7TQ54 Q9D4C4

UniProt Splice Variant

Entrez Gene

16890

UniGene

Mm.158548 Mm.333679

RefSeq

NM_001039507 NM_010719 XM_006539570 XM_006539571 XM_006539572

OMIM

CCDS

CCDS20981 CCDS20982

HPRD

IMGT

MGI ID

MGI:96790

MGI Symbol

Lipe

EMBL

AC162443 AC169209 AF179427 AF452490 AK016633 AK029984 AK169858 BC021642 CH466593 U08188 U12765

GenPept

AAA50232 AAC52163 AAC53069 AAH21642 AAP84985 BAB30349 BAC26716 BAE41414 EDL24271

RNA Seq Atlas

16890