Mus musculus Gene: Tcf7l1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-157940.7 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Tcf7l1 | ||||||||||||||||||||||
Gene Name | transcription factor 7 like 1 (T cell specific, HMG box) | ||||||||||||||||||||||
Synonyms | bHLHb21; Tcf-3; Tcf3 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000055799 | ||||||||||||||||||||||
Encoded Proteins |
transcription factor 7-like 1 (T-cell specific, HMG box)
transcription factor 7-like 1 (T-cell specific, HMG box)
transcription factor 7-like 1 (T-cell specific, HMG box)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152284:
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 6:72626378-72789254 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | C1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG |
Endometrial cancer pathway
Basal cell carcinoma pathway
Acute myeloid leukemia pathway
Melanogenesis pathway
Wnt signaling pathway pathway
Colorectal cancer pathway
Thyroid cancer pathway
Adherens junction pathway
Prostate cancer pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Pathways in cancer pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Degradation of beta-catenin by the destruction complex pathway
truncated APC mutants destabilize the destruction complex pathway
binding of TCF/LEF:CTNNB1 to target gene promoters pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
Ca2+ pathway pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
beta-catenin independent WNT signaling pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
APC truncation mutants have impaired AXIN binding pathway
deactivation of the beta-catenin transactivating complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Signal Transduction pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
repression of WNT target genes pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
formation of the beta-catenin:TCF transactivating complex pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
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KEGG |
Acute myeloid leukemia pathway
Colorectal cancer pathway
Wnt signaling pathway pathway
Thyroid cancer pathway
Adherens junction pathway
Endometrial cancer pathway
Prostate cancer pathway
Basal cell carcinoma pathway
Melanogenesis pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
Pathways in cancer pathway
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INOH |
Wnt signaling pathway pathway
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PID NCI |
Regulation of nuclear beta catenin signaling and target gene transcription
Validated transcriptional targets of deltaNp63 isoforms
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | F6VNH1 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 21415 | ||||||||||||||||||||||
UniGene | Mm.440067 | ||||||||||||||||||||||
RefSeq | NM_001079822 NM_009332 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS20245 CCDS39517 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1202876 | ||||||||||||||||||||||
MGI Symbol | Tcf7l1 | ||||||||||||||||||||||
EMBL | AC125039 AC153613 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 21415 | ||||||||||||||||||||||