InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ppard

Summary

InnateDB Gene

IDBG-158082.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppard

Gene Name

peroxisome proliferator activator receptor delta

Synonyms

Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta; PPAR[b]; Pparb; Pparb/d; PPARdelta

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002250

Encoded Proteins

IDBP-158084

peroxisome proliferator activator receptor delta

IDBP-625020

peroxisome proliferator activator receptor delta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112033:
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:28232754-28301469

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000002320	ENSMUSP00000002320
ENSMUST00000144200
ENSMUST00000123020
ENSMUST00000142226
ENSMUST00000166744
ENSMUST00000169040	ENSMUSP00000133077

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003713	transcription coactivator activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005504	fatty acid binding
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0008289	lipid binding
GO:0016501	prostacyclin receptor activity
GO:0043565	sequence-specific DNA binding
GO:0046965	retinoid X receptor binding
GO:0046982	protein heterodimerization activity
GO:0051059	NF-kappaB binding
GO:0070539	linoleic acid binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001890	placenta development
GO:0006029	proteoglycan metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006776	vitamin A metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007507	heart development
GO:0007566	embryo implantation
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008366	axon ensheathment
GO:0008544	epidermis development
GO:0008654	phospholipid biosynthetic process
GO:0009299	mRNA transcription
GO:0009749	response to glucose
GO:0009987	cellular process
GO:0010033	response to organic substance
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823	response to activity
GO:0014912	negative regulation of smooth muscle cell migration
GO:0015908	fatty acid transport
GO:0019395	fatty acid oxidation
GO:0030154	cell differentiation
GO:0030308	negative regulation of cell growth
GO:0030522	intracellular receptor signaling pathway
GO:0031589	cell-substrate adhesion
GO:0032024	positive regulation of insulin secretion
GO:0032966	negative regulation of collagen biosynthetic process
GO:0033189	response to vitamin A
GO:0042060	wound healing
GO:0042127	regulation of cell proliferation
GO:0042640	anagen
GO:0043066	negative regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043401	steroid hormone mediated signaling pathway
GO:0043616	keratinocyte proliferation
GO:0045598	regulation of fat cell differentiation
GO:0045684	positive regulation of epidermis development
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045909	positive regulation of vasodilation
GO:0046697	decidualization
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050728	negative regulation of inflammatory response
GO:0050796	regulation of insulin secretion
GO:0051546	keratinocyte migration
GO:0060612	adipose tissue development
GO:0071456	cellular response to hypoxia
GO:0097190	apoptotic signaling pathway