Mus musculus Gene: Abl1 | |||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-158216.6 | ||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||
Gene Symbol | Abl1 | ||||||||||||||||||||||||||||||||||||||
Gene Name | c-abl oncogene 1, non-receptor tyrosine kinase | ||||||||||||||||||||||||||||||||||||||
Synonyms | Abl; AI325092; c-Abl; E430008G22Rik | ||||||||||||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000026842 | ||||||||||||||||||||||||||||||||||||||
Encoded Proteins |
c-abl oncogene 1, non-receptor tyrosine kinase
c-abl oncogene 1, non-receptor tyrosine kinase
c-abl oncogene 1, non-receptor tyrosine kinase
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Protein Structure | |||||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||||||||||
Summary |
ABL1 kinase is required for neutrophil migration.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||
Summary |
[Homo sapiens] ABL1 kinase is required for neutrophil migration.
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Entrez Gene | |||||||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000097007:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008] This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5\' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] |
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Gene Information | |||||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 2:31688376-31804227 | ||||||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||
Band | B | ||||||||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 268 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||||||
REACTOME |
Innate Immune System pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Hemostasis pathway
Immune System pathway
Myogenesis pathway
Signaling by Robo receptor pathway
Role of Abl in Robo-Slit signaling pathway
Factors involved in megakaryocyte development and platelet production pathway
CDO in myogenesis pathway
Axon guidance pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Developmental Biology pathway
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KEGG |
Axon guidance pathway
ErbB signaling pathway pathway
Cell cycle pathway
Chronic myeloid leukemia pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Viral myocarditis pathway
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INOH | |||||||||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||
NETPATH |
Alpha6Beta4Integrin pathway
EGFR1 pathway
KitReceptor pathway
TCR pathway
RANKL pathway
FSH pathway
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REACTOME |
Regulation of actin dynamics for phagocytic cup formation pathway
Factors involved in megakaryocyte development and platelet production pathway
CDO in myogenesis pathway
Role of Abl in Robo-Slit signaling pathway
Signaling by Robo receptor pathway
Developmental Biology pathway
Innate Immune System pathway
Axon guidance pathway
Myogenesis pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Hemostasis pathway
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KEGG |
Pathogenic Escherichia coli infection pathway
ErbB signaling pathway pathway
Cell cycle pathway
Axon guidance pathway
Chronic myeloid leukemia pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Viral myocarditis pathway
Shigellosis pathway
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INOH | |||||||||||||||||||||||||||||||||||||||
PID NCI |
Regulation of retinoblastoma protein
p53 pathway
Neurotrophic factor-mediated Trk receptor signaling
p73 transcription factor network
ATM pathway
Validated transcriptional targets of TAp63 isoforms
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-beta signaling pathway
Regulation of Telomerase
Posttranslational regulation of adherens junction stability and dissassembly
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Cross-References | |||||||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||||
UniGene | Mm.1318 | ||||||||||||||||||||||||||||||||||||||
RefSeq | NM_001112703 NM_001283045 NM_001283046 NM_001283047 NM_009594 | ||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||
CCDS | CCDS15901 CCDS50563 | ||||||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||