InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prkg1

Summary

InnateDB Gene

IDBG-158230.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkg1

Gene Name

protein kinase, cGMP-dependent, type I

Synonyms

AW125416; CGKI; Gm19690; Prkg1b; Prkgr1b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052920

Encoded Proteins

IDBP-158232

protein kinase, cGMP-dependent, type I

IDBP-158234

protein kinase, cGMP-dependent, type I

IDBP-789638

protein kinase, cGMP-dependent, type I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185532:
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:30567551-31765033

Strand

Reverse strand

Band

Transcripts

ENSMUST00000065067	ENSMUSP00000067576
ENSMUST00000073581	ENSMUSP00000073268
ENSMUST00000183135
ENSMUST00000182459
ENSMUST00000182527
ENSMUST00000182401
ENSMUST00000182685	ENSMUSP00000138208

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004692	cGMP-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030553	cGMP binding

Biological Process

GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0016358	dendrite development
GO:0019934	cGMP-mediated signaling
GO:0030900	forebrain development
GO:0043087	regulation of GTPase activity
GO:0045986	negative regulation of smooth muscle contraction
GO:0060087	relaxation of vascular smooth muscle
GO:0090331	negative regulation of platelet aggregation