Homo sapiens Gene: DGCR8
Summary
InnateDB Gene IDBG-1583.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DGCR8
Gene Name DiGeorge syndrome critical region gene 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128191
Encoded Proteins
DiGeorge syndrome critical region gene 8
DiGeorge syndrome critical region gene 8
DiGeorge syndrome critical region gene 8
DiGeorge syndrome critical region gene 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:20080232-20111877
Strand Forward strand
Band q11.21
Transcripts
ENST00000351989 ENSP00000263209
ENST00000383024 ENSP00000372488
ENST00000407755 ENSP00000384726
ENST00000457069 ENSP00000409625
ENST00000495826
ENST00000498171
ENST00000491892
ENST00000495351
ENST00000485802
ENST00000475941
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0010467 gene expression
GO:0031053 primary miRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
MicroRNA (miRNA) biogenesis pathway
Gene Expression pathway
Regulatory RNA pathways pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
Cross-References
SwissProt Q8WYQ5
TrEMBL C9JSD5
UniProt Splice Variant
Entrez Gene 54487
UniGene Hs.606163 Hs.643452 Hs.732256
RefSeq NM_001190326 NM_022720 XM_006724268
HUGO HGNC:2847
OMIM 609030
CCDS CCDS13773 CCDS54501
HPRD
IMGT
EMBL AB050770 AC006547 AF165527 AK025539 AK025780 AK313357 AY189282 BC009323 BC009984 BC078147 BX649187 CR456356
GenPept AAF82263 AAH09323 AAH09984 AAH78147 AAO86726 BAB15165 BAB15238 BAB83032 BAG36158 CAE46205 CAG30242
RNA Seq Atlas 100302197 54487