Homo sapiens Gene: NTAN1 | |||||||
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Summary | |||||||
InnateDB Gene | IDBG-15842.6 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | NTAN1 | ||||||
Gene Name | N-terminal asparagine amidase | ||||||
Synonyms | |||||||
Species | Homo sapiens | ||||||
Ensembl Gene | ENSG00000157045 | ||||||
Encoded Proteins |
N-terminal asparagine amidase
N-terminal asparagine amidase
N-terminal asparagine amidase
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Protein Structure | |||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||
Entrez Gene | |||||||
Summary |
The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012] |
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Gene Information | |||||||
Type | Protein coding | ||||||
Genomic Location | Chromosome 16:15037853-15056079 | ||||||
Strand | Reverse strand | ||||||
Band | p13.11 | ||||||
Transcripts | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||
SwissProt | |||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | |||||||
UniGene | Hs.592045 | ||||||
RefSeq | NM_001270766 NM_001270767 NM_173474 | ||||||
HUGO | |||||||
OMIM | |||||||
CCDS | CCDS10558 CCDS73832 | ||||||
HPRD | 17649 | ||||||
IMGT | |||||||
EMBL | |||||||
GenPept | |||||||
RNA Seq Atlas | |||||||