InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sumo1

Summary

InnateDB Gene

IDBG-158495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sumo1

Gene Name

SMT3 suppressor of mif two 3 homolog 1 (yeast)

Synonyms

GMP1; PIC1; SENTRIN; SMT3; Smt3C; SMT3H3; SMTP3; SUMO-1; Ubl1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026021

Encoded Proteins

IDBP-130315

SMT3 suppressor of mif two 3 homolog 1 (yeast)

IDBP-790059

SMT3 suppressor of mif two 3 homolog 1 (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116030:
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:59586558-59670834

Strand

Reverse strand

Band

Transcripts

ENSMUST00000091374	ENSMUSP00000088935
ENSMUST00000123857
ENSMUST00000191158
ENSMUST00000185265	ENSMUSP00000140729

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 669 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	669 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006950	response to stress
GO:0016925	protein sumoylation
GO:0030578	PML body organization
GO:0031334	positive regulation of protein complex assembly
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060021	palate development
GO:0090204	protein localization to nuclear pore

Cellular Component

GO:0001650	fibrillar center
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016604	nuclear body
GO:0016605	PML body
GO:0016607	nuclear speck
GO:0030425	dendrite
GO:0031965	nuclear membrane
GO:0045202	synapse