Version 5.4
Mus musculus Gene: Dapk1
Summary
InnateDB Gene IDBG-159357.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dapk1
Gene Name death associated protein kinase 1
Synonyms D13Ucla1; DAP-Kinase
Species Mus musculus
Ensembl Gene ENSMUSG00000021559
Encoded Proteins
IDBP-159359
death associated protein kinase 1
IDBP-159361
death associated protein kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196730:
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. [provided by RefSeq, Jul 2008]
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:60601947-60763185
Strand Forward strand
Band B2
Transcripts
ENSMUST00000044083 ENSMUSP00000040825
ENSMUST00000077453 ENSMUSP00000076666
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0042802 identical protein binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009103 lipopolysaccharide biosynthetic process
GO:0017148 negative regulation of translation
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0071346 cellular response to interferon-gamma
GO:0097190 apoptotic signaling pathway
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196730
View Gene Order
ENSBTAG00000000738
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_252543
Role of DCC in regulating apoptosis pathway
REACT_227606
Regulation of Apoptosis pathway
KEGG
mmu05219
Bladder cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22128
Role of DCC in regulating apoptosis pathway
REACT_578
Apoptosis pathway
REACT_13648
Regulation of Apoptosis pathway
KEGG
hsa05219
Bladder cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
netrin_pathway
Netrin-mediated signaling events
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.24103
RefSeq NM_001285917 NM_029653 NM_134062 XM_006517369 XM_006517370 XM_006517371
OMIM
CCDS CCDS26581
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca