InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il2rb

Summary

InnateDB Gene

IDBG-159374.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il2rb

Gene Name

interleukin 2 receptor, beta chain

Synonyms

CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta; IL15Rbeta; p70

Species

Mus musculus

Ensembl Gene

ENSMUSG00000068227

Encoded Proteins

IDBP-159376

interleukin 2 receptor, beta chain

IDBP-627507

interleukin 2 receptor, beta chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26668377

Selective loss of the histone-lysine N-methyltransferase Ezh2 (enhancer of zeste homolog 2) or inhibition of its enzymatic activity increases generation of the Il2rb (CD122) natural killer (NK) precursors and mature NK progeny.

InnateDB Annotation from Orthologs

Summary

PMID 8700888

[Homo sapiens] IL2RB is phosphorylated by JAK1and different IL2RB tyrosines couple to at least two signalling pathways (JAK-STAT and SHC-coupled) and synergistically mediate IL2-induced proliferation.

PMID 8041779

[Homo sapiens] IL2RB physically associates with JAK1 suggesting that regulation of JAK1 may be linked to IL2 induced signal transduction.

Entrez Gene

Summary

The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:78480553-78495066

Strand

Reverse strand

Band

Transcripts

ENSMUST00000089398	ENSMUSP00000086820
ENSMUST00000163494	ENSMUSP00000127006

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004911	interleukin-2 receptor activity
GO:0005515	protein binding
GO:0019976	interleukin-2 binding

Biological Process

GO:0019221	cytokine-mediated signaling pathway
GO:0038110	interleukin-2-mediated signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)