Version 5.4
Mus musculus Gene: Il10ra
Summary
InnateDB Gene IDBG-159458.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il10ra
Gene Name interleukin 10 receptor, alpha
Synonyms AW553859; CDw210; CDw210a; Il10r; mIL-10R
Species Mus musculus
Ensembl Gene ENSMUSG00000032089
Encoded Proteins
IDBP-159460
interleukin 10 receptor, alpha
IDBP-741798
IDBP-742261
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110324:
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:45253837-45269149
Strand Reverse strand
Band A5.2
Transcripts
ENSMUST00000034594 ENSMUSP00000034594
ENSMUST00000176222 ENSMUSP00000135461
ENSMUST00000176808 ENSMUSP00000135361
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004920 interleukin-10 receptor activity
GO:0005515 protein binding
GO:0019969 interleukin-10 binding
Biological Process
GO:0019221 cytokine-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000110324
View Gene Order
ENSBTAG00000005215
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu05145
Toxoplasmosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-10 signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-10 signaling pathway
PID NCI
Cross-References
SwissProt Q61727
TrEMBL H3BKE8 H3BKN6 Q3UDL4
UniProt Splice Variant
Entrez Gene 16154
UniGene Mm.379327
RefSeq NM_008348
OMIM
CCDS CCDS23131
HPRD
IMGT
MGI ID MGI:96538
MGI Symbol Il10ra
EMBL AC166051 AK137663 AK150022 AK159566 CH466522 L12120
GenPept AAA16156 BAE23452 BAE29247 BAE35189 EDL25643
RNA Seq Atlas 16154

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca