InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ndufs1

Summary

InnateDB Gene

IDBG-160282.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufs1

Gene Name

NADH dehydrogenase (ubiquinone) Fe-S protein 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025968

Encoded Proteins

IDBP-160284

NADH dehydrogenase (ubiquinone) Fe-S protein 1

IDBP-628240

NADH dehydrogenase (ubiquinone) Fe-S protein 1

IDBP-789191

NADH dehydrogenase (ubiquinone) Fe-S protein 1

IDBP-789193

NADH dehydrogenase (ubiquinone) Fe-S protein 1

IDBP-789195

NADH dehydrogenase (ubiquinone) Fe-S protein 1

IDBP-789196

NADH dehydrogenase (ubiquinone) Fe-S protein 1

IDBP-789197

NADH dehydrogenase (ubiquinone) Fe-S protein 1

IDBP-789199

NADH dehydrogenase (ubiquinone) Fe-S protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000023228:
The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:63143596-63176833

Strand

Reverse strand

Band

Transcripts

ENSMUST00000027111	ENSMUSP00000027111
ENSMUST00000140612
ENSMUST00000168099	ENSMUSP00000126621
ENSMUST00000190095
ENSMUST00000187835
ENSMUST00000187756	ENSMUSP00000140072
ENSMUST00000185847	ENSMUSP00000141190
ENSMUST00000186569
ENSMUST00000185827
ENSMUST00000188370	ENSMUSP00000139664
ENSMUST00000185732	ENSMUSP00000140307
ENSMUST00000185412	ENSMUSP00000140467
ENSMUST00000189664	ENSMUSP00000140819

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0008637	apoptotic mitochondrial changes
GO:0042773	ATP synthesis coupled electron transport
GO:0045333	cellular respiration
GO:0046034	ATP metabolic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process