InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lgals1

Summary

InnateDB Gene

IDBG-160341.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lgals1

Gene Name

lectin, galactose binding, soluble 1

Synonyms

AA410090; Gal-1; Galbp; galectin-1; L-14.5; L14; Lect14

Species

Mus musculus

Ensembl Gene

ENSMUSG00000068220

Encoded Proteins

IDBP-160343

lectin, galactose binding, soluble 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19561030

[Homo sapiens] LGALS1, the prototype of a family of beta-galactoside-binding proteins, is involved in monocyte chemoattraction at sites of inflammation where it stimulates monocyte migration in a dose-dependent manner via the p44/42 MAP kinase pathway.

PMID 26589797

[Homo sapiens] LGALS1 and LGALS3 play opposing roles in the inflammatory responses to Trichomonas vaginalis infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100097:
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:78926725-78930465

Strand

Forward strand

Band

Transcripts

ENSMUST00000089377

ENSMUSP00000086795

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005534	galactose binding
GO:0016936	galactoside binding
GO:0030246	carbohydrate binding
GO:0030395	lactose binding
GO:0042803	protein homodimerization activity
GO:0043236	laminin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002317	plasma cell differentiation
GO:0006915	apoptotic process
GO:0007157	heterophilic cell-cell adhesion
GO:0007165	signal transduction
GO:0010812	negative regulation of cell-substrate adhesion
GO:0010977	negative regulation of neuron projection development
GO:0031295	T cell costimulation
GO:0033555	multicellular organismal response to stress
GO:0034120	positive regulation of erythrocyte aggregation
GO:0042493	response to drug
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045445	myoblast differentiation
GO:0048678	response to axon injury
GO:0071333	cellular response to glucose stimulus
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000100097

View Gene Order

ENSBTAG00000015089

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

myc_represspathway

Validated targets of C-MYC transcriptional repression

ras_pathway

Regulation of Ras family activation

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.469547

RefSeq

NM_008495

OMIM

CCDS

CCDS27628

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas