InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dctn1

Summary

InnateDB Gene

IDBG-160591.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dctn1

Gene Name

dynactin 1

Synonyms

AL022633; Glued; p150; p150

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031865

Encoded Proteins

IDBP-160593

dynactin 1

IDBP-252852

dynactin 1

IDBP-252854

dynactin 1

IDBP-252856

dynactin 1

IDBP-252858

dynactin 1

IDBP-532738

dynactin 1

IDBP-541393

dynactin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204843:
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:83165920-83200117

Strand

Forward strand

Band

Transcripts

ENSMUST00000077407	ENSMUSP00000076623
ENSMUST00000113919	ENSMUSP00000109552
ENSMUST00000113918	ENSMUSP00000109551
ENSMUST00000113913	ENSMUSP00000109546
ENSMUST00000113907	ENSMUSP00000109540
ENSMUST00000130212	ENSMUSP00000115838
ENSMUST00000141680	ENSMUSP00000121538
ENSMUST00000123313
ENSMUST00000127824
ENSMUST00000154420
ENSMUST00000130917
ENSMUST00000153793

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0045502	dynein binding
GO:0048037	cofactor binding

Biological Process

GO:0008152	metabolic process
GO:0010970	microtubule-based transport
GO:0031122	cytoplasmic microtubule organization
GO:0032402	melanosome transport
GO:0090316	positive regulation of intracellular protein transport

Cellular Component

GO:0000776	kinetochore
GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005869	dynactin complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0030286	dynein complex
GO:0031252	cell leading edge
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000204843

View Gene Order

ENSBTAG00000004887

Not yet available

Pathways

NETPATH

REACTOME

REACT_245720

Recruitment of mitotic centrosome proteins and complexes pathway

REACT_240530

G2/M Transition pathway

REACT_249770

Cell Cycle, Mitotic pathway

REACT_243078

Loss of Nlp from mitotic centrosomes pathway

REACT_239697

Unfolded Protein Response (UPR) pathway

REACT_188804

Cell Cycle pathway

REACT_230745

Immune System pathway

REACT_247926

Metabolism of proteins pathway

REACT_231085

IRE1alpha activates chaperones pathway

REACT_246508

Mitotic G2-G2/M phases pathway

REACT_196550

MHC class II antigen presentation pathway

REACT_244487

Loss of proteins required for interphase microtubule organization�? from the centrosome pathway

REACT_196635

Regulation of PLK1 Activity at G2/M Transition pathway

REACT_229531

Adaptive Immune System pathway

REACT_106572

XBP1(S) activates chaperone genes pathway

REACT_253753

Centrosome maturation pathway

KEGG

mmu05016

Huntington's disease pathway

mmu04962

Vasopressin-regulated water reabsorption pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_121399

MHC class II antigen presentation pathway

REACT_18273

XBP1(S) activates chaperone genes pathway

REACT_18368

IRE1alpha activates chaperones pathway

REACT_18356

Unfolded Protein Response (UPR) pathway

REACT_17015

Metabolism of proteins pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa05016

Huntington's disease pathway

hsa04962

Vasopressin-regulated water reabsorption pathway

INOH

PID NCI

ncadherinpathway

N-cadherin signaling events

Cross-References

SwissProt

TrEMBL

D3YYG9

UniProt Splice Variant

Entrez Gene

13191

UniGene

Mm.6919

RefSeq

NM_001198866 NM_001198867 NM_007835 XM_006505485 XM_006505486 XM_006505487 XM_006505488 XM_006505489 XM_006505490 XM_006505491 XM_006505492 XM_006505493 XM_006505494 XM_006505495

OMIM

CCDS

CCDS39532 CCDS57432 CCDS57433

HPRD

IMGT

MGI ID

MGI:107745

MGI Symbol

Dctn1

EMBL

AC160400

GenPept

RNA Seq Atlas

13191