InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pafah1b2

Summary

InnateDB Gene

IDBG-160930.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pafah1b2

Gene Name

platelet-activating factor acetylhydrolase, isoform 1b, subunit 2

Synonyms

AI747451; AU021353; mus[b]; Pafahb

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003131

Encoded Proteins

IDBP-621873

platelet-activating factor acetylhydrolase, isoform 1b, subunit 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168092:
Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [providedby RefSeq, May 2010]
Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:45965311-45984871

Strand

Reverse strand

Band

A5.2

Transcripts

ENSMUST00000172450

ENSMUSP00000127851

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0005515	protein binding
GO:0016788	hydrolase activity, acting on ester bonds
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006928	cellular component movement
GO:0007283	spermatogenesis
GO:0007420	brain development
GO:0016042	lipid catabolic process
GO:0016239	positive regulation of macroautophagy

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000168092

View Gene Order

ENSBTAG00000005627

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00565

Ether lipid metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00565

Ether lipid metabolism pathway

INOH

PID NCI

lis1pathway

Lissencephaly gene (LIS1) in neuronal migration and development

Cross-References

SwissProt

Q61206

TrEMBL

UniProt Splice Variant

Entrez Gene

18475

UniGene

Mm.200859 Mm.393954 Mm.408199 Mm.414030 Mm.470875

RefSeq

NM_008775 XM_006510081 XM_006510082 XM_006510083 XM_006510084 XM_006510085

OMIM

CCDS

CCDS23139

HPRD

IMGT

MGI ID

MGI:108415

MGI Symbol

Pafah1b2

EMBL

AK153424 BC002037 BC056211 U57747

GenPept

AAC52997 AAH02037 AAH56211 BAE31983

RNA Seq Atlas

18475