Mus musculus Gene: Nfatc1
Summary
InnateDB Gene IDBG-161489.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nfatc1
Gene Name nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Synonyms 2210017P03Rik; AI449492; AV076380; NF-ATc; NFAT2; NFATc; Nfatcb;
Species Mus musculus
Ensembl Gene ENSMUSG00000033016
Encoded Proteins
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131196:
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2008]
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:80606205-80713071
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000078049 ENSMUSP00000077196
ENSMUST00000035800 ENSMUSP00000046312
ENSMUST00000170905 ENSMUSP00000129001
ENSMUST00000167977 ENSMUSP00000126884
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 9 [view]
Protein-DNA 16 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001837 epithelial to mesenchymal transition
GO:0006355 regulation of transcription, DNA-templated
GO:0006816 calcium ion transport
GO:0007507 heart development
GO:0010628 positive regulation of gene expression
GO:0030316 osteoclast differentiation
GO:0035556 intracellular signal transduction
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
MAPK signaling pathway pathway
Wnt signaling pathway pathway
Osteoclast differentiation pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TCR pathway
RANKL pathway
REACTOME
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by Wnt pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
Ca2+ pathway pathway
Signal Transduction pathway
beta-catenin independent WNT signaling pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
KEGG
MAPK signaling pathway pathway
Wnt signaling pathway pathway
Osteoclast differentiation pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
INOH
PID BIOCARTA
Signaling pathway from g-protein families [Biocarta view]
Bcr signaling pathway [Biocarta view]
Effects of calcineurin in keratinocyte differentiation [Biocarta view]
Nfat and hypertrophy of the heart [Biocarta view]
Gata3 participate in activating the th2 cytokine genes expression [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
PID NCI
Downstream signaling in na´ve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
BCR signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt
TrEMBL Q9DBQ6
UniProt Splice Variant
Entrez Gene 18018
UniGene Mm.329560 Mm.410368
RefSeq NM_001164109 NM_016791 NM_001164111 NM_198429 NM_001164110 NM_001164112
OMIM
CCDS CCDS29369 CCDS37873 CCDS50336 CCDS50335
HPRD
IMGT
MGI ID MGI:102469
MGI Symbol Nfatc1
EMBL AC123818 AC149054 AK004810 EU887571
GenPept ACG55591 BAB23581
RNA Seq Atlas 18018