Version 5.4
Mus musculus Gene: Fgfbp1
Summary
InnateDB Gene IDBG-161594.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fgfbp1
Gene Name fibroblast growth factor binding protein 1
Synonyms FGF-BP; FGF-BP1; FGFBP-1
Species Mus musculus
Ensembl Gene ENSMUSG00000048373
Encoded Proteins
IDBP-161596
fibroblast growth factor binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137440:
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:43978865-43981762
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000061299 ENSMUSP00000056900
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017134 fibroblast growth factor binding
Biological Process
GO:0008284 positive regulation of cell proliferation
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137440
View Gene Order
ENSBTAG00000031497
Not yet available
Cross-References
SwissProt O70514
TrEMBL
UniProt Splice Variant
Entrez Gene 14181
UniGene Mm.46053
RefSeq NM_001271616 NM_008009 XM_006503711 XM_006503712
OMIM
CCDS CCDS19268
HPRD
IMGT
MGI ID MGI:1096350
MGI Symbol Fgfbp1
EMBL AF065441 AK146625 BC065774 U49641
GenPept AAB05227 AAC17439 AAH65774 BAE27314
RNA Seq Atlas 14181

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca