InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Zwint

Summary

InnateDB Gene

IDBG-161923.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zwint

Gene Name

ZW10 interactor

Synonyms

2010007E07Rik; 2600001N01Rik; D10Ertd749e; Zwint-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019923

Encoded Proteins

IDBP-161925

ZW10 interactor

IDBP-270894

ZW10 interactor

IDBP-538813

ZW10 interactor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122952:
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:72654845-72674964

Strand

Forward strand

Band

B5.3

Transcripts

ENSMUST00000020081	ENSMUSP00000020081
ENSMUST00000105431	ENSMUSP00000101071
ENSMUST00000160337	ENSMUSP00000124429
ENSMUST00000160128
ENSMUST00000163046
ENSMUST00000159549

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0007093	mitotic cell cycle checkpoint
GO:0051649	establishment of localization in cell

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0043231	intracellular membrane-bounded organelle