Version 5.4
Mus musculus Gene: Mbp
Summary
InnateDB Gene IDBG-161984.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mbp
Gene Name myelin basic protein
Synonyms C76307; golli-mbp; Hmbpr; mld; R75289; shi
Species Mus musculus
Ensembl Gene ENSMUSG00000041607
Encoded Proteins
IDBP-161986
myelin basic protein
IDBP-161988
myelin basic protein
IDBP-161990
myelin basic protein
IDBP-161992
myelin basic protein
IDBP-161994
myelin basic protein
IDBP-161996
myelin basic protein
IDBP-251250
myelin basic protein
IDBP-251252
myelin basic protein
IDBP-788945
myelin basic protein
IDBP-537490
myelin basic protein
IDBP-535637
myelin basic protein
IDBP-541263
myelin basic protein
IDBP-541256
myelin basic protein
IDBP-533797
myelin basic protein
IDBP-540275
myelin basic protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the \'shiverer\' and \'myelin deficient\' phenotypes in mouse. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:82475146-82585637
Strand Forward strand
Band E3
Transcripts
ENSMUST00000047865 ENSMUSP00000046185
ENSMUST00000091789 ENSMUSP00000089393
ENSMUST00000062446 ENSMUSP00000053495
ENSMUST00000075372 ENSMUSP00000074836
ENSMUST00000080658 ENSMUSP00000079488
ENSMUST00000102812 ENSMUSP00000099876
ENSMUST00000114676 ENSMUSP00000110324
ENSMUST00000114674 ENSMUSP00000110322
ENSMUST00000143506 ENSMUSP00000138313
ENSMUST00000152071 ENSMUSP00000115409
ENSMUST00000142850 ENSMUSP00000115082
ENSMUST00000133193 ENSMUSP00000116019
ENSMUST00000123251 ENSMUSP00000121855
ENSMUST00000153478 ENSMUSP00000114630
ENSMUST00000132369 ENSMUSP00000114230
ENSMUST00000150952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005515 protein binding
GO:0019911 structural constituent of myelin sheath
Biological Process
GO:0007568 aging
GO:0009636 response to toxic substance
GO:0021762 substantia nigra development
GO:0032570 response to progesterone
GO:0034612 response to tumor necrosis factor
GO:0042552 myelination
GO:0046689 response to mercury ion
GO:0050771 negative regulation of axonogenesis
GO:0061024 membrane organization
GO:0070542 response to fatty acid
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0033269 internode region of axon
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043209 myelin sheath
GO:0043218 compact myelin
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000197971
View Gene Order
ENSBTAG00000022890
Not yet available
Cross-References
SwissProt P04370
TrEMBL
UniProt Splice Variant
Entrez Gene 17196
UniGene Mm.252063 Mm.392350 Mm.440081
RefSeq NM_010777 NM_001025245 NM_001025251 NM_001025254 NM_001025255 NM_001025256 NM_001025258 NM_001025259 XM_006526453 XM_006526456 XM_006526457 XM_006526458
OMIM
CCDS CCDS29373 CCDS29374 CCDS29376 CCDS29377 CCDS29378 CCDS29379 CCDS37875
HPRD
IMGT
MGI ID MGI:96925
MGI Symbol Mbp
EMBL AK005129 BC004704 K00989 L00398 L00399 L00400 L00401 L00402 L00403 L00404 L07504 L07505 L07507 L07508 L07509 M11291 M11529 M11530 M11531 M11532 M11533 M15060 M15062 M20010 M24410 M36275 X67319
GenPept AAA37719 AAA37720 AAA37721 AAA37722 AAA39495 AAA39496 AAA39497 AAA39498 AAA39499 AAA39500 AAA39501 AAA39502 AAA39503 AAA39504 AAB59711 AAB59712 AAH04704 BAB23830 CAA47733
RNA Seq Atlas 17196

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca