Homo sapiens Gene: SNX1
Summary
InnateDB Gene IDBG-16207.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNX1
Gene Name sorting nexin 1
Synonyms HsT17379; VPS5;
Species Homo sapiens
Ensembl Gene ENSG00000028528
Encoded Proteins
sorting nexin 1
sorting nexin 1
sorting nexin 1
sorting nexin 1
sorting nexin 1
sorting nexin 1
sorting nexin 1
sorting nexin 1
sorting nexin 1
sorting nexin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:64094123-64146090
Strand Forward strand
Band q22.31
Transcripts
ENST00000380285 ENSP00000369638
ENST00000261889 ENSP00000261889
ENST00000560829 ENSP00000452651
ENST00000559061 ENSP00000452652
ENST00000559844 ENSP00000453785
ENST00000560260 ENSP00000452759
ENST00000561026 ENSP00000453567
ENST00000558040 ENSP00000452668
ENST00000559389 ENSP00000452852
ENST00000559401
ENST00000559339
ENST00000559961
ENST00000560861 ENSP00000452931
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
Experimentally validated
Total 58 [view]
Protein-Protein 55 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0016197 endosomal transport
GO:0034498 early endosome to Golgi transport
GO:0042147 retrograde transport, endosome to Golgi
GO:0045732 positive regulation of protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030904 retromer complex
GO:0031901 early endosome membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
PAR1-mediated thrombin signaling events
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.188634 Hs.695096 Hs.703547
RefSeq NM_001242933 NM_003099 NM_148955 XM_005254610 XM_005254611
HUGO
OMIM
CCDS CCDS32266 CCDS32268 CCDS58371
HPRD 03171
IMGT
EMBL
GenPept
RNA Seq Atlas