Version 5.4
Mus musculus Gene: Zbtb16
Summary
InnateDB Gene IDBG-162201.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zbtb16
Gene Name zinc finger and BTB domain containing 16
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000066687
Encoded Proteins
IDBP-162203
zinc finger and BTB domain containing 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25705792
[Homo sapiens] MIR146A upregulation by CXCR4 antagonist AMD3100 treatment or ZBTB16 silencing, decreases CXCR4 protein expression and prevents HIV-1 infection of leukemic monocytic cell line and CD4(+) T lymphocytes.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109906:
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:48654311-48835945
Strand Reverse strand
Band A5.3
Transcripts
ENSMUST00000093852 ENSMUSP00000091374
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 103 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 103 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001501 skeletal system development
GO:0001823 mesonephros development
GO:0006355 regulation of transcription, DNA-templated
GO:0007417 central nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0009880 embryonic pattern specification
GO:0009952 anterior/posterior pattern specification
GO:0030097 hemopoiesis
GO:0032332 positive regulation of chondrocyte differentiation
GO:0034504 protein localization to nucleus
GO:0035116 embryonic hindlimb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0043065 positive regulation of apoptotic process
GO:0045600 positive regulation of fat cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045778 positive regulation of ossification
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048133 male germ-line stem cell division
GO:0051138 positive regulation of NK T cell differentiation
GO:0051216 cartilage development
GO:0061036 positive regulation of cartilage development
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016604 nuclear body
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109906
View Gene Order
ENSBTAG00000011266
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05221
Acute myeloid leukemia pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.457803
RefSeq NM_001033324 XM_006510258
OMIM
CCDS CCDS23158
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca