Version 5.4
Mus musculus Gene: Fam125b
Summary
InnateDB Gene IDBG-162818.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fam125b
Gene Name family with sequence similarity 125, member B
Synonyms 2610200O14Rik; 2610528K11Rik; AI414895; Fam125b
Species Mus musculus
Ensembl Gene ENSMUSG00000038740
Encoded Proteins
IDBP-162820
family with sequence similarity 125, member B
IDBP-539096
family with sequence similarity 125, member B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196814:
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:33729953-33887946
Strand Reverse strand
Band B
Transcripts
ENSMUST00000041555 ENSMUSP00000048901
ENSMUST00000148660 ENSMUSP00000115744
ENSMUST00000146892
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0015031 protein transport
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
Cellular Component
GO:0000813 ESCRT I complex
GO:0005634 nucleus
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0031902 late endosome membrane
GO:0031982 vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000196814
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2ARF0
UniProt Splice Variant
Entrez Gene 72543
UniGene Mm.254914
RefSeq NM_175184
OMIM
CCDS CCDS15946
HPRD
IMGT
MGI ID MGI:1919793
MGI Symbol Mvb12b
EMBL AL845360 BX649361
GenPept
RNA Seq Atlas 72543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca