InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mtap

Summary

InnateDB Gene

IDBG-162824.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtap

Gene Name

methylthioadenosine phosphorylase

Synonyms

1300019I21Rik; MSAP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000062937

Encoded Proteins

IDBP-162826

methylthioadenosine phosphorylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099810:
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:89137122-89181081

Strand

Forward strand

Band

Transcripts

ENSMUST00000058030	ENSMUSP00000061092
ENSMUST00000134429

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004645	phosphorylase activity
GO:0017061	S-methyl-5-thioadenosine phosphorylase activity

Biological Process

GO:0006166	purine ribonucleoside salvage
GO:0008150	biological_process
GO:0009116	nucleoside metabolic process
GO:0019509	L-methionine biosynthetic process from methylthioadenosine
GO:0033574	response to testosterone