InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hspa5

Summary

InnateDB Gene

IDBG-163151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspa5

Gene Name

heat shock protein 5

Synonyms

AL022860; AU019543; baffled; Bip; D2Wsu141e; D2Wsu17e; Grp78; Hsce70; mBiP; SEZ-7; Sez7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026864

Encoded Proteins

IDBP-163153

heat shock protein 5

IDBP-163155

heat shock protein 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000044574:
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:34771970-34776531

Strand

Forward strand

Band

Transcripts

ENSMUST00000028222	ENSMUSP00000028222
ENSMUST00000100171	ENSMUSP00000097747
ENSMUST00000137505
ENSMUST00000137145
ENSMUST00000145466
ENSMUST00000148308
ENSMUST00000155595
ENSMUST00000129333

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 216 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	216 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0031625	ubiquitin protein ligase binding
GO:0043022	ribosome binding
GO:0051082	unfolded protein binding
GO:0051787	misfolded protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006983	ER overload response
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0021589	cerebellum structural organization
GO:0021680	cerebellar Purkinje cell layer development
GO:0021762	substantia nigra development
GO:0030335	positive regulation of cell migration
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031398	positive regulation of protein ubiquitination
GO:0034976	response to endoplasmic reticulum stress
GO:0035437	maintenance of protein localization in endoplasmic reticulum
GO:0040019	positive regulation of embryonic development
GO:0042149	cellular response to glucose starvation
GO:0043066	negative regulation of apoptotic process
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0071236	cellular response to antibiotic
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005790	smooth endoplasmic reticulum
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0008180	COP9 signalosome
GO:0009986	cell surface
GO:0016020	membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0030496	midbody
GO:0034663	endoplasmic reticulum chaperone complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome