Version 5.4
Homo sapiens Gene: THOP1
Summary
InnateDB Gene IDBG-16324.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THOP1
Gene Name thimet oligopeptidase 1
Synonyms EP24.15; MEPD_HUMAN; MP78; TOP
Species Homo sapiens
Ensembl Gene ENSG00000172009
Encoded Proteins
IDBP-16326
thimet oligopeptidase 1
IDBP-240012
thimet oligopeptidase 1
IDBP-759900
IDBP-766227
IDBP-759823
IDBP-763743
IDBP-762448
IDBP-764443
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:2785460-2815807
Strand Forward strand
Band p13.3
Transcripts
ENST00000307741 ENSP00000304467
ENST00000395212 ENSP00000378638
ENST00000589087
ENST00000590970 ENSP00000465855
ENST00000587401 ENSP00000465895
ENST00000592639
ENST00000590533
ENST00000586677 ENSP00000467226
ENST00000585338 ENSP00000465545
ENST00000587468 ENSP00000464786
ENST00000586780
ENST00000585673
ENST00000591149
ENST00000591363 ENSP00000466653
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004929
View Gene Order
ENSBTAG00000020446
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04614
Renin-angiotensin system pathway
hsa05143
African trypanosomiasis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.78769
RefSeq NM_003249
HUGO
OMIM
CCDS CCDS12095
HPRD 03072
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca