Version 5.4
Mus musculus Gene: Paf1
Summary
InnateDB Gene IDBG-163408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Paf1
Gene Name Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Synonyms 5730511K23Rik; AA675045
Species Mus musculus
Ensembl Gene ENSMUSG00000003437
Encoded Proteins
IDBP-163410
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006712:
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:28392951-28399388
Strand Forward strand
Band B1
Transcripts
ENSMUST00000003529 ENSMUSP00000003529
ENSMUST00000146604
ENSMUST00000122857
ENSMUST00000143201
ENSMUST00000132910
ENSMUST00000154823
ENSMUST00000152512
ENSMUST00000146886
ENSMUST00000145339
ENSMUST00000146913
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000993 RNA polymerase II core binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001711 endodermal cell fate commitment
GO:0006351 transcription, DNA-templated
GO:0006378 mRNA polyadenylation
GO:0010390 histone monoubiquitination
GO:0016055 Wnt signaling pathway
GO:0019827 stem cell maintenance
GO:0031442 positive regulation of mRNA 3'-end processing
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523 histone H2B ubiquitination
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005739 mitochondrion
GO:0016593 Cdc73/Paf1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000006712
View Gene Order
ENSBTAG00000020428
Not yet available
Cross-References
SwissProt Q8K2T8
TrEMBL
UniProt Splice Variant
Entrez Gene 54624
UniGene Mm.7916
RefSeq NM_019458
OMIM
CCDS CCDS21043
HPRD
IMGT
MGI ID MGI:1923988
MGI Symbol Paf1
EMBL AB041615 AK017762 AK134857 AK148538 BC029843 BC083337
GenPept AAH29843 AAH83337 BAA95098 BAB30913 BAE22315 BAE28608
RNA Seq Atlas 54624

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca