InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hells

Summary

InnateDB Gene

IDBG-163438.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hells

Gene Name

helicase, lymphoid specific

Synonyms

AI323785; E130115I21Rik; LSH; Lysh; PASG; YFK8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025001

Encoded Proteins

IDBP-163440

helicase, lymphoid specific

IDBP-537977

helicase, lymphoid specific

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119969:
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:38930915-38971051

Strand

Forward strand

Band

Transcripts

ENSMUST00000025965	ENSMUSP00000025965
ENSMUST00000138292
ENSMUST00000145051	ENSMUSP00000116710
ENSMUST00000155465
ENSMUST00000128949
ENSMUST00000127968

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0001655	urogenital system development
GO:0006306	DNA methylation
GO:0006342	chromatin silencing
GO:0006346	methylation-dependent chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0007067	mitotic nuclear division
GO:0007275	multicellular organismal development
GO:0010216	maintenance of DNA methylation
GO:0030098	lymphocyte differentiation
GO:0031508	centromeric heterochromatin assembly
GO:0043066	negative regulation of apoptotic process
GO:0046651	lymphocyte proliferation
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0005634	nucleus
GO:0005721	centromeric heterochromatin

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000119969

View Gene Order

ENSBTAG00000005979

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

deltanp63pathway

Validated transcriptional targets of deltaNp63 isoforms

Cross-References

SwissProt

TrEMBL

D3Z414

UniProt Splice Variant

Entrez Gene

15201

UniGene

Mm.474558 Mm.57223

RefSeq

NM_008234 XM_006526699 XM_006526700

OMIM

CCDS

CCDS29789

HPRD

IMGT

MGI ID

MGI:106209

MGI Symbol

Hells

EMBL

AC101775

GenPept

RNA Seq Atlas

15201