InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gabrg2

Summary

InnateDB Gene

IDBG-163458.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gabrg2

Gene Name

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

Synonyms

GABAA-R; Gabrg-2; gamma2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020436

Encoded Proteins

IDBP-163460

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

IDBP-163462

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

IDBP-262704

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a gamma-aminobutyric acid (GABA)-A receptor subunit, which is a member of the ligand-gated ion channel family. GABA is the major inhibitory neurotransmitter in the adult central nervous system, and conversely exhibits an excitatory function during development. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. This gene encodes one of three gamma subunits in mammals, which contain the binding site for benzodiazepine drugs. Several mutations in this gene are associated with epileptic seizures, and genetic knockdown is associated with anxiety behavior. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:41910203-42000857

Strand

Reverse strand

Band

Transcripts

ENSMUST00000070725	ENSMUSP00000064739
ENSMUST00000070735	ENSMUSP00000063812
ENSMUST00000109290	ENSMUSP00000104913
ENSMUST00000146198

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007268	synaptic transmission
GO:0009791	post-embryonic development
GO:0030534	adult behavior
GO:0034220	ion transmembrane transport
GO:0051932	synaptic transmission, GABAergic
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0032590	dendrite membrane
GO:0034707	chloride channel complex
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060077	inhibitory synapse