InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Il18

Summary

InnateDB Gene

IDBG-163502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il18

Gene Name

interleukin 18

Synonyms

Igif; Il-18

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039217

Encoded Proteins

IDBP-163504

interleukin 18

IDBP-742396

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22940097

Il18 secreted by inflammatory monocytes is critical for the differentiation of CD8(+) T and NK lymphocytes into antimicrobial effector cells.

PMID 24549849

Both Nlrp3 and Nlrp1a are important regulators of Toxoplasma proliferation and Il18 signaling is required to mediate host resistance to acute toxoplasmosis.

PMID 25395539

Flagellin induces Tlr5-dependent Il22 production and Nlrc4-dependent Il18 production to promote a protective gene expression program in intestinal epithelial cells and elimination of rotavirus-infected cells.

PMID 25689249

Activation of the Nlrp3 inflammasome is detrimental during leishmaniasis. Mice lacking the inflammasome components Nlrp3, Pycard, Casp1 exhibit defective Il1b and Il18 production at the infection site and are resistant to cutaneous Leishmania major infection.

PMID 25680273

Il22 augments the expression of Il18 mRNA and inactive precursor protein (proIL-18) in intestinal epithelial cells after Toxoplasma gondii or Citrobacter rodentium infection and maintains the homeostatic amount of proIL-18 in the ileum.

PMID 26638072

Microbiota-associated metabolites modulate Nlrp6 inflammasome signalling, epithelial Il18 secretion, and anti-microbial pathways.

PMID 26638073

Colitis severity is controlled at the level of Il18 signalling in intestinal epithelial cells.

InnateDB Annotation from Orthologs

Summary

PMID 20195505

[Homo sapiens] IL18 and IL1B are important pro-inflammatory cytokines that activates monocytes, macropages, and neutrophils, as well as induce the Th1 and Th17 adaptive cellular responses.

PMID 22940097

[Homo sapiens] IL18 secreted by inflammatory monocytes is critical for the differentiation of memory CD8(+) T and NK lymphocytes into antimicrobial effector cells. (Demonstrated in mice)

PMID 25732728

[Homo sapiens] Primary γδ T cells provide an early source of IFNG during dengue virus (DV) infection and target DV-infected cells. Monocytes also participate as accessory cells that sense DV infection and amplify the cellular immune response in an IL18-dependent manner.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150782:
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:50575273-50581837

Strand

Forward strand

Band

A5.3

Transcripts

ENSMUST00000059081	ENSMUSP00000054591
ENSMUST00000180021	ENSMUSP00000137193

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	5 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0000165	MAPK cascade
GO:0001525	angiogenesis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0010628	positive regulation of gene expression
GO:0030101	natural killer cell activation
GO:0030155	regulation of cell adhesion
GO:0030431	sleep
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729	positive regulation of interferon-gamma production
GO:0032740	positive regulation of interleukin-17 production
GO:0032819	positive regulation of natural killer cell proliferation
GO:0042088	T-helper 1 type immune response
GO:0042095	interferon-gamma biosynthetic process
GO:0042104	positive regulation of activated T cell proliferation
GO:0042231	interleukin-13 biosynthetic process
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0045087	innate immune response (InnateDB)
GO:0051142	positive regulation of NK T cell proliferation
GO:0071407	cellular response to organic cyclic compound