InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sod3

Summary

InnateDB Gene

IDBG-163718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sod3

Gene Name

superoxide dismutase 3, extracellular

Synonyms

AI314465; EC-SOD

Species

Mus musculus

Ensembl Gene

ENSMUSG00000072941

Encoded Proteins

IDBP-163720

superoxide dismutase 3, extracellular

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109610:
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:52363946-52371405

Strand

Forward strand

Band

Transcripts

ENSMUST00000101208

ENSMUSP00000098768

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004784	superoxide dismutase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0001666	response to hypoxia
GO:0006801	superoxide metabolic process
GO:0006979	response to oxidative stress
GO:0019430	removal of superoxide radicals
GO:0046688	response to copper ion
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005796	Golgi lumen
GO:0005802	trans-Golgi network
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000109610

View Gene Order

ENSBTAG00000013980

Not yet available

Pathways

NETPATH

REACTOME

REACT_188957

Cellular responses to stress pathway

REACT_189141

Detoxification of Reactive Oxygen Species pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_172715

Detoxification of Reactive Oxygen Species pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

O09164

TrEMBL

Q542X9

UniProt Splice Variant

Entrez Gene

20657

UniGene

Mm.2407

RefSeq

NM_011435

OMIM

CCDS

CCDS19283

HPRD

IMGT

MGI ID

MGI:103181

MGI Symbol

Sod3

EMBL

AF223251 AK075570 D50856 U38261

GenPept

AAB51106 AAF27932 BAA23493 BAC35828

RNA Seq Atlas

20657