InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Efna1

Summary

InnateDB Gene

IDBG-163736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Efna1

Gene Name

ephrin A1

Synonyms

AI325262; B61; Efl1; Epl1; Eplg1; Lerk1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027954

Encoded Proteins

IDBP-163738

ephrin A1

IDBP-401098

ephrin A1

IDBP-401097

ephrin A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169242:
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:89271733-89281142

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029566	ENSMUSP00000029566
ENSMUST00000118860	ENSMUSP00000113098
ENSMUST00000118587	ENSMUSP00000112904

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0003180	aortic valve morphogenesis
GO:0003183	mitral valve morphogenesis
GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0007411	axon guidance
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0014028	notochord formation
GO:0016477	cell migration
GO:0030182	neuron differentiation
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0034446	substrate adhesion-dependent cell spreading
GO:0043535	regulation of blood vessel endothelial cell migration
GO:0045765	regulation of angiogenesis
GO:0048013	ephrin receptor signaling pathway
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050770	regulation of axonogenesis
GO:0061002	negative regulation of dendritic spine morphogenesis