Version 5.4
Mus musculus Gene: Derl3
Summary
InnateDB Gene IDBG-163982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Derl3
Gene Name Der1-like domain family, member 3
Synonyms 1810006I20Rik; 1810063P04Rik; derlin-3; IZP6
Species Mus musculus
Ensembl Gene ENSMUSG00000009092
Encoded Proteins
IDBP-163984
Der1-like domain family, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099958:
The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:75893398-75895941
Strand Forward strand
Band C1
Transcripts
ENSMUST00000009236 ENSMUSP00000009236
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
Cellular Component
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000099958
View Gene Order
ENSBTAG00000022028
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q9D8K3
TrEMBL Q14C34
UniProt Splice Variant
Entrez Gene 70377
UniGene Mm.275878
RefSeq NM_024440 XM_006514079
OMIM
CCDS CCDS23935
HPRD
IMGT
MGI ID MGI:1917627
MGI Symbol Derl3
EMBL AB047555 AK007348 AK007948 AK172429 BC004729 BC115466 BC115467 CH466553
GenPept AAH04729 AAI15467 AAI15468 BAB24977 BAB25367 BAB32788 BAE43003 EDL31877
RNA Seq Atlas 70377

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca