InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slu7

Summary

InnateDB Gene

IDBG-164064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slu7

Gene Name

SLU7 splicing factor homolog (S. cerevisiae)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020409

Encoded Proteins

IDBP-164066

SLU7 splicing factor homolog (S. cerevisiae)

IDBP-537195

SLU7 splicing factor homolog (S. cerevisiae)

IDBP-538417

SLU7 splicing factor homolog (S. cerevisiae)

IDBP-718020

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:43433744-43447981

Strand

Forward strand

Band

B1.1

Transcripts

ENSMUST00000020681	ENSMUSP00000020681
ENSMUST00000151880	ENSMUSP00000116609
ENSMUST00000126128	ENSMUSP00000122142
ENSMUST00000149402
ENSMUST00000136541
ENSMUST00000178622	ENSMUSP00000137281

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000386	second spliceosomal transesterification activity
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0030628	pre-mRNA 3'-splice site binding

Biological Process

GO:0000375	RNA splicing, via transesterification reactions
GO:0000380	alternative mRNA splicing, via spliceosome
GO:0000389	mRNA 3'-splice site recognition
GO:0006886	intracellular protein transport
GO:0034605	cellular response to heat

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016607	nuclear speck
GO:0030532	small nuclear ribonucleoprotein complex
GO:0043231	intracellular membrane-bounded organelle
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000164609

View Gene Order

ENSBTAG00000008457

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03040

Spliceosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

Q8BHJ9

TrEMBL

B0QZT9 Z4YM25

UniProt Splice Variant

Entrez Gene

193116

UniGene

Mm.28200

RefSeq

NM_148673 NM_198936 XM_006532582

OMIM

CCDS

CCDS24557

HPRD

IMGT

MGI ID

MGI:2385598

MGI Symbol

Slu7

EMBL

AK029117 AK046262 AK047597 AK049178 AL670472 BC013810 BC023057 BC060954 BC082780 BC106099

GenPept

AAH13810 AAH23057 AAH60954 AAH82780 AAI06100 BAC26306 BAC32662 BAC33093 BAC33589 CAI24830 CAI24831

RNA Seq Atlas

193116