Version 5.4
Homo sapiens Gene: SKP2
Summary
InnateDB Gene IDBG-16420.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SKP2
Gene Name S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Synonyms FBL1; FBXL1; FLB1; p45
Species Homo sapiens
Ensembl Gene ENSG00000145604
Encoded Proteins
IDBP-16422
S-phase kinase-associated protein 2 (p45)
IDBP-16424
S-phase kinase-associated protein 2 (p45)
IDBP-479715
S-phase kinase-associated protein 2 (p45)
IDBP-475573
S-phase kinase-associated protein 2 (p45)
IDBP-477390
S-phase kinase-associated protein 2 (p45)
IDBP-476628
S-phase kinase-associated protein 2 (p45)
IDBP-475266
S-phase kinase-associated protein 2 (p45)
IDBP-598612
S-phase kinase-associated protein 2 (p45)
IDBP-808781
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 27194766
IFI27 restricts viral infection by recruiting an E3 ligase, SKP2, for ubiquitination and degradation of viral protein.
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:36151989-36184319
Strand Forward strand
Band p13.2
Transcripts
ENST00000274254 ENSP00000274254
ENST00000274255 ENSP00000274255
ENST00000508514 ENSP00000421941
ENST00000509692 ENSP00000426004
ENST00000513151 ENSP00000423188
ENST00000513263 ENSP00000426675
ENST00000504386 ENSP00000424234
ENST00000546211 ENSP00000443492
ENST00000620197 ENSP00000478031
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 176 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 176 [view]
Protein-Protein 168 [view]
Protein-DNA 7 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0000278 mitotic cell cycle
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008283 cell proliferation
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051726 regulation of cell cycle
GO:0071460 cellular response to cell-matrix adhesion
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016235 aggresome
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054115
View Gene Order
ENSBTAG00000013562
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_9003
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_1590
G1 Phase pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04110
Cell cycle pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa05222
Small cell lung cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
foxopathway
FoxO family signaling
p53regulationpathway
p53 pathway
myc_pathway
C-MYC pathway
foxm1pathway
FOXM1 transcription factor network
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 6502
UniGene
RefSeq NM_001243120 NM_005983 NM_032637
HUGO HGNC:10901
OMIM 601436
CCDS CCDS58944 CCDS3915 CCDS3916
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 6502

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca