InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tia1

Summary

InnateDB Gene

IDBG-164670.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tia1

Gene Name

cytotoxic granule-associated RNA binding protein 1

Synonyms

2310050N03Rik; AI256674; mTIA-1; TIA-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000071337

Encoded Proteins

IDBP-164672

cytotoxic granule-associated RNA binding protein 1

IDBP-164674

cytotoxic granule-associated RNA binding protein 1

IDBP-164676

cytotoxic granule-associated RNA binding protein 1

IDBP-253302

cytotoxic granule-associated RNA binding protein 1

IDBP-789537

cytotoxic granule-associated RNA binding protein 1

IDBP-253306

cytotoxic granule-associated RNA binding protein 1

IDBP-536478

cytotoxic granule-associated RNA binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116001:
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:86404219-86433403

Strand

Forward strand

Band

Transcripts

ENSMUST00000095753	ENSMUSP00000093425
ENSMUST00000095754	ENSMUSP00000093426
ENSMUST00000095752	ENSMUSP00000093424
ENSMUST00000113713	ENSMUSP00000109342
ENSMUST00000113712	ENSMUSP00000138652
ENSMUST00000113708	ENSMUSP00000109338
ENSMUST00000154983
ENSMUST00000141960
ENSMUST00000148728
ENSMUST00000139928
ENSMUST00000130967	ENSMUSP00000118558
ENSMUST00000154438
ENSMUST00000156762
ENSMUST00000143718
ENSMUST00000134142
ENSMUST00000136387
ENSMUST00000149270
ENSMUST00000147104
ENSMUST00000124683
ENSMUST00000123002
ENSMUST00000126404
ENSMUST00000152852
ENSMUST00000123267

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0017091	AU-rich element binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006915	apoptotic process
GO:0017148	negative regulation of translation
GO:0042036	negative regulation of cytokine biosynthetic process
GO:0048024	regulation of mRNA splicing, via spliceosome

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0097165	nuclear stress granule

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000116001

View Gene Order

ENSBTAG00000019182

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.333219 Mm.474669 Mm.488871

RefSeq

NM_001164078 NM_001164079 NM_011585

OMIM

CCDS

CCDS20312 CCDS51833 CCDS51834

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas