Version 5.4
Mus musculus Gene: Adcy2
Summary
InnateDB Gene IDBG-164683.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adcy2
Gene Name adenylate cyclase 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000021536
Encoded Proteins
IDBP-164685
adenylate cyclase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078295:
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:68620043-68999541
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000022013 ENSMUSP00000022013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004016 adenylate cyclase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008179 adenylate cyclase binding
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity
GO:0016849 phosphorus-oxygen lyase activity
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006171 cAMP biosynthetic process
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0043234 protein complex
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000078295
View Gene Order
ENSBTAG00000019210
Not yet available
Pathways
NETPATH
REACTOME
REACT_242871
G alpha (s) signalling events pathway
REACT_239142
Innate Immune System pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_188190
PLCG1 events in ERBB2 signaling pathway
REACT_223625
GPCR downstream signaling pathway
REACT_189085
Disease pathway
REACT_254215
Signaling by GPCR pathway
REACT_210399
Glucagon signaling in metabolic regulation pathway
REACT_269412
Hedgehog 'off' state pathway
REACT_217323
Integration of energy metabolism pathway
REACT_259326
Ca-dependent events pathway
REACT_203664
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_263607
PLC-gamma1 signalling pathway
REACT_213852
PKA-mediated phosphorylation of CREB pathway
REACT_222824
Adenylate cyclase inhibitory pathway pathway
REACT_188937
Metabolism pathway
REACT_220758
PKA activation in glucagon signalling pathway
REACT_230745
Immune System pathway
REACT_236516
EGFR interacts with phospholipase C-gamma pathway
REACT_207065
Activation of GABAB receptors pathway
REACT_226335
Aquaporin-mediated transport pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_240702
CaM pathway pathway
REACT_217338
Inhibition of adenylate cyclase pathway pathway
REACT_213947
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_242976
Signaling by EGFR pathway
REACT_217868
GABA B receptor activation pathway
REACT_258013
G alpha (z) signalling events pathway
REACT_230708
Phospholipase C-mediated cascade pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_224131
GABA receptor activation pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_248921
Signalling by NGF pathway
REACT_263353
Signaling by PDGF pathway
REACT_259290
Neuronal System pathway
REACT_188269
DAG and IP3 signaling pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_242845
Opioid Signalling pathway
REACT_215587
Calmodulin induced events pathway
REACT_224974
Adenylate cyclase activating pathway pathway
REACT_188257
Signal Transduction pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_242456
Signaling by FGFR pathway
REACT_253342
PLC beta mediated events pathway
REACT_248370
G-protein mediated events pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_220108
PKA activation pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04916
Melanogenesis pathway
mmu04540
Gap junction pathway
mmu04912
GnRH signaling pathway pathway
mmu00230
Purine metabolism pathway
mmu04062
Chemokine signaling pathway pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu05414
Dilated cardiomyopathy pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
mmu04114
Oocyte meiosis pathway
mmu04971
Gastric acid secretion pathway
mmu04970
Salivary secretion pathway
mmu04976
Bile secretion pathway
mmu04972
Pancreatic secretion pathway
INOH
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15530
PKA activation pathway
REACT_15497
PKA-mediated phosphorylation of CREB pathway
REACT_9000
Calmodulin induced events pathway
REACT_9053
CaM pathway pathway
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_24023
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_9417
Signaling by EGFR pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_15312
Adenylate cyclase activating pathway pathway
REACT_15333
Adenylate cyclase inhibitory pathway pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_25031
GABA B receptor activation pathway
REACT_1946
PKA activation in glucagon signalling pathway
REACT_1665
Glucagon signaling in metabolic regulation pathway
REACT_1505
Integration of energy metabolism pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_11061
Signalling by NGF pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_25199
GABA receptor activation pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_15526
G-protein mediated events pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
REACT_25282
Inhibition of adenylate cyclase pathway pathway
REACT_15307
Ca-dependent events pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_116125
Disease pathway
KEGG
hsa04912
GnRH signaling pathway pathway
hsa04540
Gap junction pathway
hsa00230
Purine metabolism pathway
hsa04020
Calcium signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04062
Chemokine signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa05414
Dilated cardiomyopathy pathway
hsa04114
Oocyte meiosis pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa04976
Bile secretion pathway
INOH
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt Q80TL1
TrEMBL Q3V1Q3
UniProt Splice Variant
Entrez Gene 210044
UniGene Mm.390617
RefSeq NM_153534 XM_006517184
OMIM
CCDS CCDS36721
HPRD
IMGT
MGI ID MGI:99676
MGI Symbol Adcy2
EMBL AC154389 AC154482 AC239879 AK122432 AK132312 BC037107 CT033781
GenPept AAH37107 BAC65714 BAE21097
RNA Seq Atlas 210044

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca