Version 5.4
| Mus musculus Gene: Gm11808 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-165030.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Gm11808 | ||||||||||
| Gene Name | predicted gene 11808 | ||||||||||
| Synonyms | |||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Gene | ENSMUSG00000068240 | ||||||||||
| Encoded Proteins |
predicted gene 11808
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000221983:
Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 4:3973092-3973595 | ||||||||||
| Strand | Reverse strand | ||||||||||
| Band | A1 | ||||||||||
| Transcripts |
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| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Circadian Clock pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
p53-Independent G1/S DNA damage checkpoint pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Autodegradation of the E3 ubiquitin ligase COP1 pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
Stimuli-sensing channels pathway
Apoptosis pathway
Oxidative Stress Induced Senescence pathway
EGFR downregulation pathway
Downregulation of TGF-beta receptor signaling pathway
G2/M Transition pathway
Mus musculus biological processes pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
G1 Phase pathway
Disease pathway
Synthesis of DNA pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
Signaling by Wnt pathway
Signaling by constitutively active EGFR pathway
Circadian Clock pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Separation of Sister Chromatids pathway
Peptide chain elongation pathway
Hedgehog 'off' state pathway
DNA Replication pathway
Signaling by WNT in cancer pathway
Membrane Trafficking pathway
Downstream TCR signaling pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Switching of origins to a post-replicative state pathway
Cellular responses to stress pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
MyD88 cascade initiated on plasma membrane pathway
degradation of DVL pathway
Loss of Function of SMAD4 in Cancer pathway
Signaling by FGFR in disease pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Signaling by ERBB4 pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
FCERI mediated NF-kB activation pathway
Degradation of beta-catenin by the destruction complex pathway
Cytokine Signaling in Immune system pathway
Oncogene Induced Senescence pathway
beta-catenin independent WNT signaling pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway
Cellular response to hypoxia pathway
p53-Independent DNA Damage Response pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
p53-Dependent G1 DNA Damage Response pathway
Translation pathway
p53-Dependent G1/S DNA damage checkpoint pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
TGFBR1 LBD Mutants in Cancer pathway
AMER1 mutants destabilize the destruction complex pathway
Eukaryotic Translation Termination pathway
Cell Cycle pathway
Glucose metabolism pathway
regulation of FZD by ubiquitination pathway
TRAF6 mediated induction of TAK1 complex pathway
IRAK2 mediated activation of TAK1 complex pathway
Stabilization of p53 pathway
Negative regulators of RIG-I/MDA5 signaling pathway
Metabolism pathway
Glycogen synthesis pathway
APC/C-mediated degradation of cell cycle proteins pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Nonsense-Mediated Decay (NMD) pathway
M Phase pathway
Metabolism of proteins pathway
Cell Cycle Checkpoints pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
TGF-beta receptor signaling activates SMADs pathway
Hedgehog ligand biogenesis pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Downregulation of ERBB4 signaling pathway
ER-Phagosome pathway pathway
Cyclin D associated events in G1 pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Negative regulation of FGFR signaling pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
Spry regulation of FGF signaling pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
Loss of Function of TGFBR2 in Cancer pathway
Processing-defective Hh variants abrogate ligand secretion pathway
deactivation of the beta-catenin transactivating complex pathway
DNA Repair pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
Cap-dependent Translation Initiation pathway
activated TAK1 mediates p38 MAPK activation pathway
APC truncation mutants have impaired AXIN binding pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Regulation of DNA replication pathway
Cellular Senescence pathway
Fanconi Anemia pathway pathway
Orc1 removal from chromatin pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
M/G1 Transition pathway
PCP/CE pathway pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Regulation of Apoptosis pathway
Mitotic G2-G2/M phases pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Activation of NF-kappaB in B cells pathway
Degradation of GLI2 by the proteasome pathway
Eukaryotic Translation Initiation pathway
Signaling by EGFR pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
p75NTR recruits signalling complexes pathway
Signaling by NOTCH2 pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
Regulation of mitotic cell cycle pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
APC/C:Cdc20 mediated degradation of Securin pathway
G1/S DNA Damage Checkpoints pathway
Degradation of GLI1 by the proteasome pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Hh ligand biogenesis disease pathway
AXIN missense mutants destabilize the destruction complex pathway
TCF dependent signaling in response to WNT pathway
GLI3 is processed to GLI3R by the proteasome pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Mitotic Metaphase and Anaphase pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Ion channel transport pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Association of licensing factors with the pre-replicative complex pathway
Fc epsilon receptor (FCERI) signaling pathway
SRP-dependent cotranslational protein targeting to membrane pathway
G1/S Transition pathway
Toll-Like Receptors Cascades pathway
Eukaryotic Translation Elongation pathway
Removal of licensing factors from origins pathway
Signaling by Interleukins pathway
NOD1/2 Signaling Pathway pathway
APC truncation mutants are not K63 polyubiquitinated pathway
p75NTR signals via NF-kB pathway
Antigen processing-Cross presentation pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
MyD88 dependent cascade initiated on endosome pathway
Cytosolic sensors of pathogen-associated DNA pathway
Transmembrane transport of small molecules pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Mitotic G1-G1/S phases pathway
Formation of a pool of free 40S subunits pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
Glycogen storage diseases pathway
TCF7L2 mutants don't bind CTBP pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
Signalling by NGF pathway
Gene Expression pathway
Adaptive Immune System pathway
NF-kB is activated and signals survival pathway
truncations of AMER1 destabilize the destruction complex pathway
Loss of Function of TGFBR1 in Cancer pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Ubiquitin-dependent degradation of Cyclin D pathway
Regulation of innate immune responses to cytosolic DNA pathway
Activated TLR4 signalling pathway
IKK complex recruitment mediated by RIP1 pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signaling by Hedgehog pathway
degradation of AXIN pathway
Asymmetric localization of PCP proteins pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Interleukin-1 signaling pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Generic Transcription Pathway pathway
MyD88-independent cascade pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Cyclin E associated events during G1/S transition pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
p75 NTR receptor-mediated signalling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
truncated APC mutants destabilize the destruction complex pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
NRIF signals cell death from the nucleus pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
Downregulation of ERBB2:ERBB3 signaling pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Signaling by FGFR pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Signaling by NOTCH pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
DNA Replication Pre-Initiation pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
TCR signaling pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Myoclonic epilepsy of Lafora pathway
Mitotic Anaphase pathway
Signaling by EGFR in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Regulation of signaling by CBL pathway
Loss of Function of SMAD2/3 in Cancer pathway
Metabolism of carbohydrates pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
IRAK1 recruits IKK complex pathway
Regulation of the Fanconi anemia pathway pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
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| KEGG |
Ribosome pathway
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| INOH | |||||||||||
| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Autodegradation of the E3 ubiquitin ligase COP1 pathway
Stabilization of p53 pathway
p53-Dependent G1 DNA Damage Response pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
p53-Independent DNA Damage Response pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
APC/C:Cdc20 mediated degradation of Securin pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Association of licensing factors with the pre-replicative complex pathway
Separation of Sister Chromatids pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
Switching of origins to a post-replicative state pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Assembly of the pre-replicative complex pathway
Cyclin E associated events during G1/S transition pathway
Cyclin D associated events in G1 pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
ER-Phagosome pathway pathway
Negative regulators of RIG-I/MDA5 signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
activated TAK1 mediates p38 MAPK activation pathway
TRAF6 mediated induction of TAK1 complex pathway
IKK complex recruitment mediated by RIP1 pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
IRAK1 recruits IKK complex pathway
IRAK2 mediated activation of TAK1 complex pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
NOD1/2 Signaling Pathway pathway
Downstream TCR signaling pathway
ISG15 antiviral mechanism pathway
Interleukin-1 signaling pathway
Regulation of signaling by CBL pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Activation of NF-kappaB in B cells pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Stimuli-sensing channels pathway
p75NTR recruits signalling complexes pathway
NF-kB is activated and signals survival pathway
NRIF signals cell death from the nucleus pathway
EGFR downregulation pathway
Signaling by EGFR pathway
Downregulation of ERBB4 signaling pathway
Signaling by ERBB4 pathway
Downregulation of TGF-beta receptor signaling pathway
TGF-beta receptor signaling activates SMADs pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
Downregulation of ERBB2:ERBB3 signaling pathway
Signaling by ERBB2 pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
Spry regulation of FGF signaling pathway
Negative regulation of FGFR signaling pathway
Signaling by FGFR pathway
Degradation of beta-catenin by the destruction complex pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Formation of a pool of free 40S subunits pathway
Eukaryotic Translation Termination pathway
Peptide chain elongation pathway
Eukaryotic Translation Elongation pathway
SRP-dependent cotranslational protein targeting to membrane pathway
Circadian Clock pathway
Vif-mediated degradation of APOBEC3G pathway
Membrane binding and targetting of GAG proteins pathway
Vpu mediated degradation of CD4 pathway
Signaling by constitutively active EGFR pathway
Viral mRNA Translation pathway
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Generic Transcription Pathway pathway
Late Phase of HIV Life Cycle pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
Regulation of the Fanconi anemia pathway pathway
Fanconi Anemia pathway pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
DNA Replication pathway
Signaling by FGFR in disease pathway
PCP/CE pathway pathway
truncated APC mutants destabilize the destruction complex pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Eukaryotic Translation Initiation pathway
G1 Phase pathway
Cellular responses to stress pathway
Transmembrane transport of small molecules pathway
p53-Independent G1/S DNA damage checkpoint pathway
Processing-defective Hh variants abrogate ligand secretion pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
FCERI mediated NF-kB activation pathway
Oncogene Induced Senescence pathway
Signalling by NGF pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
AMER1 mutants destabilize the destruction complex pathway
Influenza Infection pathway
Disease pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Nonsense-Mediated Decay (NMD) pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Synthesis of DNA pathway
Signaling by WNT in cancer pathway
APC/C-mediated degradation of cell cycle proteins pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Myoclonic epilepsy of Lafora pathway
beta-catenin independent WNT signaling pathway
TCR signaling pathway
AXIN missense mutants destabilize the destruction complex pathway
Regulation of mitotic cell cycle pathway
Antiviral mechanism by IFN-stimulated genes pathway
Glycogen synthesis pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by Wnt pathway
Mitotic G1-G1/S phases pathway
Signaling by NOTCH1 in Cancer pathway
Cytokine Signaling in Immune system pathway
S Phase pathway
Metabolism of carbohydrates pathway
Innate Immune System pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
degradation of DVL pathway
GLI3 is processed to GLI3R by the proteasome pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
deactivation of the beta-catenin transactivating complex pathway
Fc epsilon receptor (FCERI) signaling pathway
p75 NTR receptor-mediated signalling pathway
Synthesis And Processing Of GAG, GAGPOL Polyproteins pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Degradation of GLI1 by the proteasome pathway
p75NTR signals via NF-kB pathway
Influenza Viral RNA Transcription and Replication pathway
Translation pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
DNA Replication Pre-Initiation pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
G1/S Transition pathway
Apoptosis pathway
Signal Transduction pathway
Interferon Signaling pathway
Hedgehog 'off' state pathway
MAP kinase activation in TLR cascade pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
Regulation of innate immune responses to cytosolic DNA pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Hh ligand biogenesis disease pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
Ubiquitin-dependent degradation of Cyclin D pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
Antigen processing-Cross presentation pathway
regulation of FZD by ubiquitination pathway
Signaling by NOTCH2 pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Signaling by NOTCH1 pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Metabolism of proteins pathway
Adaptive Immune System pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Immune System pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Ion channel transport pathway
Cellular response to hypoxia pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
truncations of AMER1 destabilize the destruction complex pathway
M Phase pathway
Cellular Senescence pathway
HIV Life Cycle pathway
Hedgehog ligand biogenesis pathway
Mitotic Anaphase pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Signaling by Interleukins pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
G2/M Transition pathway
Cap-dependent Translation Initiation pathway
Asymmetric localization of PCP proteins pathway
M/G1 Transition pathway
degradation of AXIN pathway
TGFBR1 KD Mutants in Cancer pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Cell Cycle, Mitotic pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
HIV Infection pathway
Activated TLR4 signalling pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Class I MHC mediated antigen processing & presentation pathway
Influenza Life Cycle pathway
G1/S DNA Damage Checkpoints pathway
Mitotic G2-G2/M phases pathway
Signal Transduction pathway
Metabolism pathway
Assembly Of The HIV Virion pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Host Interactions of HIV factors pathway
Regulation of DNA replication pathway
Cytosolic sensors of pathogen-associated DNA pathway
Signaling by the B Cell Receptor (BCR) pathway
Oxidative Stress Induced Senescence pathway
Signaling by NOTCH pathway
Budding and maturation of HIV virion pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Regulation of Apoptosis pathway
Gene Expression pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
DNA Repair pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Signaling by TGF-beta Receptor Complex pathway
Membrane Trafficking pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI1 by the proteasome pathway
Regulation of Apoptosis pathway
G2/M Transition pathway
ER-Phagosome pathway pathway
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
Signaling by Wnt pathway
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
Signaling by WNT in cancer pathway
Glycogen synthesis pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
S Phase pathway
Hedgehog ligand biogenesis pathway
NOD1/2 Signaling Pathway pathway
Generic Transcription Pathway pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
Signaling by EGFR pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
Negative regulation of FGFR signaling pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Metabolism of carbohydrates pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Oncogene Induced Senescence pathway
SRP-dependent cotranslational protein targeting to membrane pathway
Signaling by NOTCH pathway
IRAK2 mediated activation of TAK1 complex pathway
Mitotic G1-G1/S phases pathway
Spry regulation of FGF signaling pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
DNA Replication Pre-Initiation pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
Regulation of signaling by CBL pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Cyclin D associated events in G1 pathway
GLI3 is processed to GLI3R by the proteasome pathway
Activated TLR4 signalling pathway
Stabilization of p53 pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
M Phase pathway
MyD88-independent cascade pathway
Ion channel transport pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Signaling by ERBB4 pathway
Regulation of innate immune responses to cytosolic DNA pathway
Cytosolic sensors of pathogen-associated DNA pathway
DNA Replication pathway
activated TAK1 mediates p38 MAPK activation pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
p53-Independent G1/S DNA damage checkpoint pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Assembly of the pre-replicative complex pathway
Separation of Sister Chromatids pathway
Association of licensing factors with the pre-replicative complex pathway
MyD88:Mal cascade initiated on plasma membrane pathway
G1/S DNA Damage Checkpoints pathway
G1/S Transition pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
G1 Phase pathway
TCF dependent signaling in response to WNT pathway
Loss of Function of SMAD4 in Cancer pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
IKK complex recruitment mediated by RIP1 pathway
Signaling by FGFR pathway
Peptide chain elongation pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Class I MHC mediated antigen processing & presentation pathway
Regulation of DNA replication pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cytokine Signaling in Immune system pathway
Orc1 removal from chromatin pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
deactivation of the beta-catenin transactivating complex pathway
Cellular responses to stress pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Loss of Function of TGFBR2 in Cancer pathway
Mitotic Metaphase and Anaphase pathway
Downstream TCR signaling pathway
Myoclonic epilepsy of Lafora pathway
Mitotic Anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Gene Expression pathway
NRIF signals cell death from the nucleus pathway
Eukaryotic Translation Initiation pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Cap-dependent Translation Initiation pathway
Asymmetric localization of PCP proteins pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
regulation of FZD by ubiquitination pathway
Immune System pathway
Cell Cycle, Mitotic pathway
MAP kinase activation in TLR cascade pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
Transmembrane transport of small molecules pathway
Mitotic G2-G2/M phases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
truncations of AMER1 destabilize the destruction complex pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
Formation of a pool of free 40S subunits pathway
Ubiquitin-dependent degradation of Cyclin D pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Synthesis of DNA pathway
Signaling by the B Cell Receptor (BCR) pathway
Translation pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
Signaling by ERBB2 pathway
Toll-Like Receptors Cascades pathway
Degradation of GLI2 by the proteasome pathway
Cell Cycle pathway
Signaling by NOTCH1 in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Signal Transduction pathway
Cellular Senescence pathway
Negative regulators of RIG-I/MDA5 signaling pathway
degradation of AXIN pathway
Signaling by EGFR in Cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
NF-kB is activated and signals survival pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
TGF-beta receptor signaling activates SMADs pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
Hedgehog 'off' state pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
DNA Repair pathway
Downregulation of ERBB2:ERBB3 signaling pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Cyclin E associated events during G1/S transition pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
Signaling by NOTCH1 pathway
Metabolism of proteins pathway
Oxidative Stress Induced Senescence pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Regulation of the Fanconi anemia pathway pathway
Autodegradation of the E3 ubiquitin ligase COP1 pathway
beta-catenin independent WNT signaling pathway
p53-Independent DNA Damage Response pathway
Fanconi Anemia pathway pathway
Glycogen storage diseases pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Regulation of mitotic cell cycle pathway
PCP/CE pathway pathway
M/G1 Transition pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
TCF7L2 mutants don't bind CTBP pathway
Glucose metabolism pathway
p75NTR recruits signalling complexes pathway
p53-Dependent G1 DNA Damage Response pathway
Signaling by constitutively active EGFR pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
Metabolism pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Signalling by NGF pathway
AMER1 mutants destabilize the destruction complex pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
FCERI mediated NF-kB activation pathway
APC/C-mediated degradation of cell cycle proteins pathway
Downregulation of TGF-beta receptor signaling pathway
Processing-defective Hh variants abrogate ligand secretion pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
Adaptive Immune System pathway
Signaling by Hedgehog pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Activation of NF-kappaB in B cells pathway
MyD88 dependent cascade initiated on endosome pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Downregulation of ERBB4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
Regulation of PLK1 Activity at G2/M Transition pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Nonsense-Mediated Decay (NMD) pathway
p75 NTR receptor-mediated signalling pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH2 pathway
degradation of DVL pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
EGFR downregulation pathway
Innate Immune System pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Stimuli-sensing channels pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Loss of Function of SMAD2/3 in Cancer pathway
Interleukin-1 signaling pathway
TGFBR1 LBD Mutants in Cancer pathway
Hh ligand biogenesis disease pathway
Removal of licensing factors from origins pathway
Cell Cycle Checkpoints pathway
Signaling by Interleukins pathway
Disease pathway
Signaling by FGFR in disease pathway
Degradation of beta-catenin by the destruction complex pathway
Eukaryotic Translation Termination pathway
Antigen processing-Cross presentation pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Switching of origins to a post-replicative state pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
IRAK1 recruits IKK complex pathway
Apoptosis pathway
MyD88 cascade initiated on plasma membrane pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
TCR signaling pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Membrane Trafficking pathway
p75NTR signals via NF-kB pathway
TRAF6 mediated induction of TAK1 complex pathway
Circadian Clock pathway
Eukaryotic Translation Elongation pathway
truncated APC mutants destabilize the destruction complex pathway
APC/C:Cdc20 mediated degradation of Securin pathway
Cellular response to hypoxia pathway
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| KEGG |
Ribosome pathway
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| INOH | |||||||||||
| PID NCI | |||||||||||
| Cross-References | |||||||||||
| SwissProt | P62984 | ||||||||||
| TrEMBL | A5JUZ1 B0LAC2 E9Q9J0 Q66JP1 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 22186 | ||||||||||
| UniGene | |||||||||||
| RefSeq | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| MGI ID | MGI:3649356 | ||||||||||
| MGI Symbol | Gm11808 | ||||||||||
| EMBL | AC157774 AF118402 AK018726 BC014772 BC054413 BC080838 BC086924 BC087922 CH466538 CH466569 EF437347 EF580991 | ||||||||||
| GenPept | AAD14688 AAH14772 AAH54413 AAH80838 AAH86924 AAH87922 ABQ52426 ABS83516 BAB31371 EDL05703 EDL28828 EDL28829 EDL28830 EDL28831 EDL28832 EDL28833 EDL28834 | ||||||||||
| RNA Seq Atlas | 22186 | ||||||||||