Mus musculus Gene: Actn4
Summary
InnateDB Gene IDBG-165033.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Actn4
Gene Name actinin alpha 4
Synonyms C77391;
Species Mus musculus
Ensembl Gene ENSMUSG00000054808
Encoded Proteins
actinin alpha 4
actinin alpha 4
actinin alpha 4
actinin alpha 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130402:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:28893248-28962340
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000068045 ENSMUSP00000066068
ENSMUST00000144909
ENSMUST00000129338
ENSMUST00000143584
ENSMUST00000127210 ENSMUSP00000115436
ENSMUST00000150493
ENSMUST00000140622 ENSMUSP00000123210
ENSMUST00000148196 ENSMUSP00000122268
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001882 nucleoside binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
GO:0047485 protein N-terminus binding
GO:0051015 actin filament binding
Biological Process
GO:0001666 response to hypoxia
GO:0015031 protein transport
GO:0042981 regulation of apoptotic process
GO:0048549 positive regulation of pinocytosis
GO:0051017 actin filament bundle assembly
GO:0051271 negative regulation of cellular component movement
GO:0051272 positive regulation of cellular component movement
GO:0070830 tight junction assembly
GO:1902396 protein localization to tight junction
Cellular Component
GO:0001725 stress fiber
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0030018 Z disc
GO:0030529 ribonucleoprotein complex
GO:0030863 cortical cytoskeleton
GO:0031143 pseudopodium
GO:0043005 neuron projection
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Hemostasis pathway
Nephrin interactions pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Cell-Cell communication pathway
KEGG
Focal adhesion pathway
Adherens junction pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Amoebiasis pathway
Systemic lupus erythematosus pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
Cell-Cell communication pathway
Nephrin interactions pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Hemostasis pathway
Platelet degranulation pathway
Nephrin interactions pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Cell-Cell communication pathway
KEGG
Focal adhesion pathway
Adherens junction pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Amoebiasis pathway
Systemic lupus erythematosus pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
INOH
PID BIOCARTA
Ucalpain and friends in cell spread [Biocarta view]
Integrin signaling pathway [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
PID NCI
PDGFR-beta signaling pathway
Cross-References
SwissProt P57780
TrEMBL D3Z0L8 D3Z761 E9Q2W9 Q3ULT2 Q61064 Q8BP35
UniProt Splice Variant
Entrez Gene 60595
UniGene Mm.81144
RefSeq NM_021895 XM_006540254 XM_006540255 XM_006540256
OMIM
CCDS CCDS21061
HPRD
IMGT
MGI ID MGI:1890773
MGI Symbol Actn4
EMBL AC166357 AJ289242 AK077839 AK145322 BC013616 BC087554 CH466593 DQ303411 U41416
GenPept AAB01089 AAH13616 AAH87554 ABC66069 BAC37028 BAE26366 CAC10069 EDL24100
RNA Seq Atlas 60595