InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Actn4

Summary

InnateDB Gene

IDBG-165033.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Actn4

Gene Name

actinin alpha 4

Synonyms

C77391

Species

Mus musculus

Ensembl Gene

ENSMUSG00000054808

Encoded Proteins

IDBP-165035

actinin alpha 4

IDBP-538974

actinin alpha 4

IDBP-534335

actinin alpha 4

IDBP-542212

actinin alpha 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130402:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:28893248-28962340

Strand

Reverse strand

Band

Transcripts

ENSMUST00000068045	ENSMUSP00000066068
ENSMUST00000144909
ENSMUST00000129338
ENSMUST00000143584
ENSMUST00000127210	ENSMUSP00000115436
ENSMUST00000150493
ENSMUST00000140622	ENSMUSP00000123210
ENSMUST00000148196	ENSMUSP00000122268

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001882	nucleoside binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0047485	protein N-terminus binding
GO:0051015	actin filament binding

Biological Process

GO:0001666	response to hypoxia
GO:0015031	protein transport
GO:0042981	regulation of apoptotic process
GO:0048549	positive regulation of pinocytosis
GO:0051017	actin filament bundle assembly
GO:0051271	negative regulation of cellular component movement
GO:0051272	positive regulation of cellular component movement
GO:0070830	tight junction assembly
GO:1902396	protein localization to tight junction

Cellular Component

GO:0001725	stress fiber
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0030018	Z disc
GO:0030529	ribonucleoprotein complex
GO:0030863	cortical cytoskeleton
GO:0031143	pseudopodium
GO:0043005	neuron projection
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome