InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fn1

Summary

InnateDB Gene

IDBG-165049.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fn1

Gene Name

fibronectin 1

Synonyms

E330027I09; Fn; Fn-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026193

Encoded Proteins

IDBP-165051

fibronectin 1

IDBP-789908

fibronectin 1

IDBP-789911

fibronectin 1

IDBP-789913

fibronectin 1

IDBP-789914

fibronectin 1

IDBP-789917

fibronectin 1

IDBP-789918

fibronectin 1

IDBP-789921

fibronectin 1

IDBP-789922

fibronectin 1

IDBP-789924

fibronectin 1

IDBP-789926

fibronectin 1

IDBP-789929

fibronectin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115414:
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:71585520-71653200

Strand

Reverse strand

Band

Transcripts

ENSMUST00000055226	ENSMUSP00000054499
ENSMUST00000188894	ENSMUSP00000140471
ENSMUST00000188674	ENSMUSP00000140907
ENSMUST00000189821	ENSMUSP00000139702
ENSMUST00000187938	ENSMUSP00000140975
ENSMUST00000190780	ENSMUSP00000140816
ENSMUST00000186129	ENSMUSP00000141123
ENSMUST00000185408
ENSMUST00000186575
ENSMUST00000187627	ENSMUSP00000140955
ENSMUST00000186985	ENSMUSP00000141193
ENSMUST00000188092
ENSMUST00000189160
ENSMUST00000186613	ENSMUSP00000140153
ENSMUST00000186940	ENSMUSP00000140315
ENSMUST00000186879
ENSMUST00000186736	ENSMUSP00000140372

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 641 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	641 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0016504	peptidase activator activity

Biological Process

GO:0001525	angiogenesis
GO:0006953	acute-phase response
GO:0007044	cell-substrate junction assembly
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007161	calcium-independent cell-matrix adhesion
GO:0008360	regulation of cell shape
GO:0010952	positive regulation of peptidase activity
GO:0018149	peptide cross-linking
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042060	wound healing
GO:0045773	positive regulation of axon extension

Cellular Component

GO:0005576	extracellular region
GO:0005577	fibrinogen complex
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005615	extracellular space
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0016324	apical plasma membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000115414

View Gene Order

ENSBTAG00000008300

Not yet available

Pathways

NETPATH

REACTOME

REACT_230203

Platelet degranulation pathway

REACT_196644

Syndecan interactions pathway

REACT_224553

Hemostasis pathway

REACT_204211

Fibronectin matrix formation pathway

REACT_198996

Elastic fibre formation pathway

REACT_198998

Molecules associated with elastic fibres pathway

REACT_225233

Cell surface interactions at the vascular wall pathway

REACT_206066

Extracellular matrix organization pathway

REACT_224879

Platelet activation, signaling and aggregation pathway

REACT_216309

Integrin cell surface interactions pathway

REACT_238268

GRB2:SOS provides linkage to MAPK signaling for Integrins pathway

REACT_196606

ECM proteoglycans pathway

REACT_196607

Non-integrin membrane-ECM interactions pathway

REACT_240371

p130Cas linkage to MAPK signaling for integrins pathway

REACT_206166

Response to elevated platelet cytosolic Ca2+ pathway

REACT_188257

Signal Transduction pathway

REACT_246176

Integrin alphaIIb beta3 signaling pathway

REACT_249309

Platelet Aggregation (Plug Formation) pathway

REACT_199052

Degradation of the extracellular matrix pathway

KEGG

mmu04512

ECM-receptor interaction pathway

mmu04810

Regulation of actin cytoskeleton pathway

mmu05222

Small cell lung cancer pathway

mmu04510

Focal adhesion pathway

mmu05200

Pathways in cancer pathway

mmu05146

Amoebiasis pathway

mmu05100

Bacterial invasion of epithelial cells pathway

INOH

INOH website

Integrin signaling pathway pathway

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_15443

GRB2:SOS provides linkage to MAPK signaling for Integrins pathway

REACT_15381

p130Cas linkage to MAPK signaling for integrins pathway

REACT_15523

Integrin alphaIIb beta3 signaling pathway

REACT_278

Platelet Aggregation (Plug Formation) pathway

REACT_318

Platelet degranulation pathway

REACT_1280

Response to elevated platelet cytosolic Ca2+ pathway

REACT_13552

Integrin cell surface interactions pathway

REACT_150331

Molecules associated with elastic fibres pathway

REACT_150366

Elastic fibre formation pathway

REACT_160131

Fibronectin matrix formation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

REACT_163942

Syndecan interactions pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_111102

Signal Transduction pathway

REACT_163906

ECM proteoglycans pathway

REACT_163874

Non-integrin membrane-ECM interactions pathway

REACT_604

Hemostasis pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04512

ECM-receptor interaction pathway

hsa05222

Small cell lung cancer pathway

hsa04510

Focal adhesion pathway

hsa05200

Pathways in cancer pathway

hsa05146

Amoebiasis pathway

hsa05100

Bacterial invasion of epithelial cells pathway

INOH

INOH website

Integrin signaling pathway pathway

PID NCI

syndecan_2_pathway

Syndecan-2-mediated signaling events

integrin1_pathway

Beta1 integrin cell surface interactions

avb3_integrin_pathway

Integrins in angiogenesis

lymphangiogenesis_pathway

VEGFR3 signaling in lymphatic endothelium

upa_upar_pathway

Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

integrin_a9b1_pathway

Alpha9 beta1 integrin signaling events

angiopoietinreceptor_pathway

Angiopoietin receptor Tie2-mediated signaling

syndecan_4_pathway

Syndecan-4-mediated signaling events

integrin_a4b1_pathway

Alpha4 beta1 integrin signaling events

integrin3_pathway

Beta3 integrin cell surface interactions

integrin5_pathway

Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001276408 NM_001276409 NM_001276410 NM_001276411 NM_001276412 NM_001276413 NM_010233

OMIM

CCDS

CCDS15031

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas