Version 5.4
Mus musculus Gene: Antxr1
Summary
InnateDB Gene IDBG-165517.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Antxr1
Gene Name anthrax toxin receptor 1
Synonyms 2310008J16Rik; 2810405N18Rik; Antrx1; Tem8
Species Mus musculus
Ensembl Gene ENSMUSG00000033420
Encoded Proteins
IDBP-165519
anthrax toxin receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169604:
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:87133854-87335775
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000042025 ENSMUSP00000045634
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0046872 metal ion binding
GO:0051015 actin filament binding
Biological Process
GO:0007165 signal transduction
GO:0022414 reproductive process
GO:0031532 actin cytoskeleton reorganization
GO:0034446 substrate adhesion-dependent cell spreading
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031258 lamellipodium membrane
GO:0031527 filopodium membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169604
View Gene Order
ENSBTAG00000007808
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.232525 Mm.398192
RefSeq NM_054041 XM_006506564
OMIM
CCDS CCDS20318
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca