Homo sapiens Gene: MRAP
Summary
InnateDB Gene IDBG-1657.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRAP
Gene Name melanocortin 2 receptor accessory protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170262
Encoded Proteins
melanocortin 2 receptor accessory protein
melanocortin 2 receptor accessory protein
melanocortin 2 receptor accessory protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:32291813-32314784
Strand Forward strand
Band q22.11
Transcripts
ENST00000303645 ENSP00000306697
ENST00000339944 ENSP00000343661
ENST00000399784 ENSP00000382684
ENST00000497833
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0031780 corticotropin hormone receptor binding
GO:0031781 type 3 melanocortin receptor binding
GO:0031782 type 4 melanocortin receptor binding
GO:0031783 type 5 melanocortin receptor binding
GO:0070996 type 1 melanocortin receptor binding
Biological Process
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0034394 protein localization to cell surface
GO:0050873 brown fat cell differentiation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt Q8TCY5
TrEMBL
UniProt Splice Variant
Entrez Gene 56246
UniGene Hs.584940
RefSeq XM_006724028 NM_178817 NM_206898
HUGO HGNC:1304
OMIM 609196
CCDS CCDS13613 CCDS13612
HPRD 10758
IMGT
EMBL AF454915 AF454916 AF483549 AY079152 BC062721
GenPept AAH62721 AAL51048 AAL51049 AAL80042 AAL86908
RNA Seq Atlas 56246