InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Smarcal1

Summary

InnateDB Gene

IDBG-165790.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smarcal1

Gene Name

SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1

Synonyms

6030401P21Rik; AI851716; Mharp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039354

Encoded Proteins

IDBP-165792

SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1

IDBP-541842

SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1

IDBP-541604

SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1

IDBP-715161

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138375:
The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:72583251-72633134

Strand

Forward strand

Band

Transcripts

ENSMUST00000047615	ENSMUSP00000047589
ENSMUST00000152814
ENSMUST00000156797
ENSMUST00000136498
ENSMUST00000145868	ENSMUSP00000120230
ENSMUST00000133123	ENSMUSP00000114848
ENSMUST00000152225	ENSMUSP00000137833
ENSMUST00000150725
ENSMUST00000126832

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008094	DNA-dependent ATPase activity
GO:0036310	annealing helicase activity

Biological Process

GO:0000733	DNA strand renaturation
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006974	cellular response to DNA damage stimulus
GO:0016568	chromatin modification
GO:0031297	replication fork processing

Cellular Component

GO:0005634	nucleus
GO:0005662	DNA replication factor A complex
GO:0035861	site of double-strand break

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000138375

View Gene Order

ENSBTAG00000003843

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

atr_pathway

ATR signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.274232 Mm.415649

RefSeq

NM_018817 XM_006496141 XM_006496142 XM_006496143 XM_006496144

OMIM

CCDS

CCDS35609

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas